Histamine reduces ZO-1 tight-junction protein expression in cultured retinal microvascular endothelial cells

被引：66
|
作者：
Gardner, TW [1 ]
Lesher, T [1 ]
Khin, S [1 ]
Vu, C [1 ]
Barber, AJ [1 ]
Brennan, WA [1 ]
机构：
[1] PENN STATE UNIV,COLL MED,DEPT CELLULAR & MOL PHYSIOL,HERSHEY,PA 17033
来源：
BIOCHEMICAL JOURNAL | 1996年 / 320卷
关键词：
D O I：
10.1042/bj3200717
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We examined ZO-1 protein content in cultured retinal vascular endothelial cells to test the hypothesis that histamine alters tight-junction-protein expression. Histamine (10(-8)-10(-4) M) causes a reversible concentration-dependent reduction of ZO-1 protein content, mediated by both H-1 and H-2 receptors. Histamine reduces ZO-1 expression within the time associated with increased paracellular permeability. Tight-junction-protein alterations may be a novel explanation for the mechanism by which vasoactive agents increase microvascular permeability.
引用
收藏
页码：717 / 721
页数：5
相关论文
共 50 条
  • [1] EXPRESSION OF THE TIGHT JUNCTION PROTEIN ZO-1 IN CULTURED RETINAL MICROVASCULAR ENDOTHELIAL AND RPE CELLS
    KENNEDY, A
    LI, C
    AMIN, R
    RUAN, H
    FRANK, RN
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1993, 34 (04) : 871 - 871
  • [2] HISTAMINE REDUCES ZO-1 TIGHT JUNCTION PROTEIN EXPRESSION IN CULTURED BOVINE RETINAL CAPILLARY ENDOTHELIAL-CELLS
    LESHER, T
    GARDNER, TW
    BREENAN, WA
    VU, C
    BONSALL, DJ
    KHIN, S
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1995, 36 (04) : S897 - S897
  • [3] ZO-1 TIGHT JUNCTION PROTEIN EXPRESSION IN CULTURED BOVINE RETINAL CAPILLARY ENDOTHELIAL-CELLS IS ENHANCED BY ASTROCYTE CONDITIONED MEDIUM
    BONSALL, DJ
    BUCKWALTER, EA
    RICE, KS
    GARDNER, TW
    LESHER, T
    BRENNAN, WA
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1994, 35 (04) : 1376 - 1376
  • [4] EXPRESSION OF TIGHT JUNCTION PROTEIN, ZO-1, IN MOUSE EMBRYOS
    SHETH, B
    COLLINS, JE
    FLEMING, TP
    MOLECULAR BIOLOGY OF THE CELL, 1995, 6 : 1118 - 1118
  • [5] ZO-1 tight junction protein expression in rat retinas
    Khin, SA
    Barber, AJ
    Gardner, TW
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1996, 37 (03) : 4444 - 4444
  • [6] Serum opens tight junctions and reduces ZO-1 protein in retinal epithelial cells
    Chang, CW
    Wang, XL
    Caldwell, RB
    JOURNAL OF NEUROCHEMISTRY, 1997, 69 (02) : 859 - 867
  • [7] VEGF/VPF reduces tight junction protein expression in cultured bovine retinal capillary endothelial cells
    Gardner, TW
    Khin, S
    Aiello, LP
    Rook, S
    Barber, A
    Lieth, E
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1997, 38 (04) : 3673 - 3673
  • [8] EXPRESSION OF THE TIGHT JUNCTION PROTEIN ZO-1 IN THE OLFACTORY SYSTEM - PRESENCE OF ZO-1 ON OLFACTORY SENSORY NEURONS AND GLIAL-CELLS
    MIRAGALL, F
    KRAUSE, D
    DEVRIES, U
    DERMIETZEL, R
    JOURNAL OF COMPARATIVE NEUROLOGY, 1994, 341 (04) : 433 - 448
  • [9] Molecular characterization of tight junction protein ZO-1 in MDCK cells
    GonzalezMariscal, L
    Islas, S
    Contreras, G
    GarciaVillegas, R
    Cereijido, M
    Valdes, J
    MOLECULAR BIOLOGY OF THE CELL, 1996, 7 : 3532 - 3532
  • [10] Molecular characterization of the tight junction protein ZO-1 in MDCK cells
    González-Mariscal, L
    Islas, S
    Contreras, RG
    García-Villegas, MR
    Betanzos, A
    Vega, J
    Diaz-Quiñónez, A
    Martín-Orozco, N
    Ortiz-Navarrete, V
    Cereijido, M
    Valdés, J
    EXPERIMENTAL CELL RESEARCH, 1999, 248 (01) : 97 - 109
12345