Targeting lipid biosynthesis and salvage in apicomplexan parasites for improved chemotherapies

被引：73

作者：

Coppens, Isabelle ^{[1
]}

机构：

[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2013年 / 11卷 / 12期

基金：

美国国家卫生研究院;

关键词：

DIPHOSPHATE/GERANYLGERANYL-DIPHOSPHATE SYNTHASE; METHYLERYTHRITOL PHOSPHATE-PATHWAY; HIGH-DENSITY-LIPOPROTEINS; PLASMODIUM LIVER-STAGE; TOXOPLASMA-GONDII; ISOPRENOID BIOSYNTHESIS; DE-NOVO; INTRAERYTHROCYTIC STAGES; CHOLESTEROL ABSORPTION; SPHINGOLIPID SYNTHESIS;

D O I：

10.1038/nrmicro3139

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Apicomplexa are some of the most widespread and poorly controlled pathogens in the world. The metabolism of lipids in these parasites, which include Plasmodium spp., Toxoplasma gondii and Cryptosporidium spp., is essential for the production of infectious progeny and pathogen persistence in their mammalian hosts. Metabolic maps of apicomplexan lipid syntheses reveal auxotrophies for many lipid species, which force these parasites to meet their high demand for lipids through networks of both synthesis and scavenging. Here, I review the unique lipid biosynthetic enzymes and lipid transporter systems of Apicomplexa, focusing on isoprenoids, sphingolipids and cholesterol, and highlight promising chemotherapeutic targets in the lipid synthetic and salvage pathways.

引用

页码：823 / 835

页数：13

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