Clinical Features and Outcome of Postoperative Peritonitis Following Bariatric Surgery

We assessed the clinical features and outcome of morbidly obese patients admitted to the intensive care unit (ICU) for management of postoperative peritonitis (POP) following bariatric surgery (BS). In a prospective, observational, surgical ICU cohort, we compared the clinical features, empiric antibiotic therapy, and prognosis of BS patients with those developing POP after conventional surgery (cPOP). Overall, 49 BS patients were compared to 134 cPOP patients. BS patients were younger (45 +/- 10 versus 63 +/- 16 years; p < 0.0001), had lower rates of fatal underlying disease (39 vs 64 %; p = 0.002), and the same SOFA score at the time of reoperation (8 +/- 4 vs 8 +/- 3; p = 0.8) as the cPOP patients. BS patients had higher proportions of Gram-positive cocci (48 vs 35 %; p = 0.007) and lower proportions of Gram-negative bacilli (33 vs 44 %; p = 0.03), anaerobes (4 vs 10 %; p = 0.04), and multidrug-resistant strains (20 vs 40 %; p = 0.01). Despite higher rates of adequate empiric antibiotic therapy (82 vs 64 %; p = 0.024) and high de-escalation rates (67 % in BS cases and 51 % in cPOP cases; p = 0.06), BS patients had similar reoperation rates (53 vs 44 %; p = 0.278) and similar mortality rates (24 vs 32 %; p = 0.32) to cPOP patients. In multivariate analysis, none of the risk factors for death were related to BS. The severity of POP in BS patients resulted in high mortality rates, similar to the results observed in cPOP. Usual empiric antibiotic therapy protocols should be applied to target multidrug-resistant microorganisms, but de-escalation can be performed in most cases.