Study of PNIPAAm-PEG thermo-sensitive copolymer micelle and application as drug carrier for icariin

被引：0
|
作者：
Xu, Xiaoyan [1 ,2 ]
Liu, Taotao [1 ]
Feng, Enke [1 ]
Zhang, Wen [1 ]
Li, Yan [1 ,2 ]
Zheng, Jun [3 ]
机构：
[1] Tongji Univ, Sch Mat Sci & Engn, Shanghai 201804, Peoples R China
[2] Minist Educ, Key Lab Adv Civil Engn Mat, Shanghai 201804, Peoples R China
[3] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Chinese & Western Med, Shanghai 200437, Peoples R China
来源：
2013 ICME INTERNATIONAL CONFERENCE ON COMPLEX MEDICAL ENGINEERING (CME) | 2013年
基金：
上海市自然科学基金; 中国国家自然科学基金;
关键词：
thermo-sensitive; PNIPAAm; PEG; icariin; BLOCK-COPOLYMER; DELIVERY;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A series of thermally responsive copolymers PNIPAAm-PEG were prepared through RAFT polymerization. Their molecular structures were verified by H-1 NMR spectroscopy and GPC. The temperature-dependent characteristics study has revealed that PNIPAAm-PEG exhibits a lower critical solution temperature (LCST) of about 34 similar to 42 degrees C with the PNIPAAm: PEG molecular weight ratio of 1:1 to 10:1. When PNIPAAm:PEG=1.8:1, the polymer has a LCST of 37.8 degrees C, which is very close to body temperature. The micelles also showed nearly 85% encapsulation efficiency for icariin with temperature dependent release. These results indicate that PNIPAAm-PEG is a promising drug carrier for icariin, and icariin-PNIPAAm-PEG has great potential in bone defect and disease treatment.
引用
收藏
页码：523 / 527
页数：5
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