Altered Negative BOLD Responses in the Default-Mode Network during Emotion Processing in Depressed Subjects

被引：270

作者：

Grimm, Simone ^{[1
]}

Boesiger, Peter ^{[2
]}

Beck, Johannes ^{[1
]}

Schuepbach, Daniel ^{[1
]}

Bermpohl, Felix ^{[3
]}

Walter, Martin ^{[4
]}

Ernst, Jutta ^{[4
]}

Hell, Daniel ^{[1
]}

Boeker, Heinz ^{[1
]}

Northoff, Georg ^{[1
,4
]}

机构：

[1] Univ Zurich, Dept Psychiat, Zurich, Switzerland

[2] ETH, Inst Biomed Engn, Div Biophys, Zurich, Switzerland

[3] Humboldt Univ, Charite, Dept Psychiat, Berlin, Germany

[4] Univ Magdeburg, Dept Psychiat, D-39120 Magdeburg, Sacshsen Anhalt, Germany

来源：

NEUROPSYCHOPHARMACOLOGY | 2009年 / 34卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

default-mode network; negative BOLD responses; major depressive disorder; event-related fMRI; emotional processing; BRAIN GLUCOSE-METABOLISM; MAJOR DEPRESSION; PREFRONTAL CORTEX; BASE-LINE; FMRI; ACTIVATION; COMPONENTS; TRIAL; ATTENUATION; RUMINATION;

D O I：

10.1038/npp.2008.81

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Studies using functional magnetic resonance imaging (fMRI) show predominant negative blood oxygenation level-dependent (BOLD) responses (NBRs) in regions of the default-mode network such as the pregenual anterior cingulate cortex, the ventromedial prefrontal cortex, and the posterior cingulate cortex. Patients with major depressive disorder (MDD) show emotional-cognitive disturbances, which have been associated with alterations within the default-mode network. However, it remains unclear whether these default-mode network alterations are related to abnormalities in NBRs. We therefore investigated neural activity in the default-mode network during different emotional tasks in patients with MDD in an event-related fMRI design. MDD patients showed significantly reduced NBRs in several regions of the default-mode network. Decreased NBRs in MDD patients correlated with depression severity and feelings of hopelessness. In sum, our findings demonstrate that default-mode network NBRs are reduced in MDD and modulate these patients' abnormally negative emotions.

引用

页码：932 / 943

页数：12

共 54 条

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