Raynaud's phenomenon and digital necrosis induced by interferon-alpha

被引：33
作者：
Bachmeyer, C
Farge, D
Gluckman, E
Miclea, JM
Aractingi, S
机构：
[1] HOP ST LOUIS,SERV MED INTERNE,CLIN MALAD CUTANEES,F-75010 PARIS,FRANCE
[2] HOP ST LOUIS,SERV GREFFE MOELLE,F-75010 PARIS,FRANCE
[3] HOP ST LOUIS,SERV CLIN MALAD SANG,F-75010 PARIS,FRANCE
来源：
BRITISH JOURNAL OF DERMATOLOGY | 1996年 / 135卷 / 03期
关键词：
D O I：
10.1111/j.1365-2133.1996.tb01521.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
We report two patients treated with interferon-alpha who developed Raynaud's phenomenon followed by multiple digital necrosis, Arteriography of the legs revealed diffuse distal narrowing, Histological examination of the resected tissue showed ischaemic necrosis within the dermis and subcutaneous tissue without vasculitis, Resolution of the symptoms was observed when interferon-alpha was withdrawn. Since other causes of Raynaud's phenomenon and digital necrosis were ruled out, a drug cause is likely, Raynaud's phenomenon should be looked for in patients treated with interferon-alpha, If present, immediate withdrawal of the drug is required.
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收藏
页码：481 / 483
页数：3
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