Synthetic applications of glucose isomerase:: isomerisation of C-5-modified (2R,3R,4R)-configured hexoses into the corresponding 2-ketoses

被引：19

作者：

Fechter, MH ^{[1
]}

Stütz, AE ^{[1
]}

机构：

[1] Graz Univ Technol, Inst Organ Chem, A-8010 Graz, Austria

来源：

CARBOHYDRATE RESEARCH | 1999年 / 319卷 / 1-4期

基金：

奥地利科学基金会;

关键词：

D-allofuranose; 2,5-dideoxy-2,5-iminoalditol; galactosidase inhibitor; glucose isomerase; L-tagatopyranose; D-psicopyranose;

D O I：

10.1016/S0008-6215(99)00119-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Immobilised glucose isomerase (EC 5.3.1.5) accepted various (2R,3R,4R)-configured hexoses such as 5-deoxy-D-ribo-hexose, 5-azido-5-deoxy-D-allose, as well as the corresponding epimer at C-5, 5-azido-5-deoxy-L-talose, as substrates. From the resulting azidodeoxyketoses, 5-azido-5-deoxy-D-psico- and -L-tagatopyranose, the powerful D-galactosidase inhibitors 2,5-dideoxy-2,5-imino-D-galactital and -D-altritol were obtained in one additional step. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：55 / 62

页数：8

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