Sex differences in the effects of androgens acting in the central nervous system on metabolism

被引：0
作者：
Morford, Jamie [1 ]
Mauvais-Jarvis, Franck [1 ]
机构：
[1] Tulane Univ, Sch Med, Dept Med, Sect Endocrinol & Metab,Hlth Sci Ctr, New Orleans, LA 70112 USA
来源：
DIALOGUES IN CLINICAL NEUROSCIENCE | 2016年 / 18卷 / 04期
关键词：
androgen; androgen receptor; arcuate nucleus; central nervous system; dihydrotestosterone; hypothalamus; metabolism; obesity; polycystic ovarian syndrome; sex difference; type; 2; diabetes; POLYCYSTIC-OVARY-SYNDROME; ANTEROVENTRAL PERIVENTRICULAR NUCLEUS; IMPAIRED GLUCOSE-TOLERANCE; FEMALE RHESUS-MONKEYS; BROWN ADIPOSE-TISSUE; INSULIN-RESISTANCE; ENERGY-EXPENDITURE; ARCUATE NUCLEUS; VENTROMEDIAL HYPOTHALAMUS; LEPTIN ACTION;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
One of the most sexually dimorphic aspects of metabolic regulation is the bidirectional modulation of glucose and energy homeostasis by testosterone in males and females. Testosterone deficiency predisposes men to metabolic dysfunction, with excess adiposity, insulin resistance, and type 2 diabetes, whereas androgen excess predisposes women to insulin resistance, adiposity, and type 2 diabetes. This review discusses how testosterone acts in the central nervous system, and especially the hypothalamus, to promote metabolic homeostasis or dysfunction in a sexually dimorphic manner. We compare the organizational actions of testosterone, which program the hypothalamic control of metabolic homeostasis during development, and the activational actions of testosterone, which affect metabolic function after puberty. We also discuss how the metabolic effect of testosterone is centrally mediated via the androgen receptor. (C) 2016, AICH - Servier Research Group
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页码：415 / 424
页数：10
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