Nitric oxide, platelet function, myocardial infarction and reperfusion therapies

被引：40
作者：
Alonso, D [1 ]
Radomski, MW [1 ]
机构：
[1] Univ Texas, Dept Integrat Biol & Pharmacol, Houston, TX 77030 USA
来源：
HEART FAILURE REVIEWS | 2003年 / 8卷 / 01期
基金：
加拿大健康研究院;
关键词：
nitric oxide; platelet function; myocardial infarction; reperfusion;
D O I：
10.1023/A:1022194921040
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Platelets play an important role in physiologic hemostasis and pathologic thrombosis that complicate the course of vascular disorders. A number of platelet functions including adhesion, aggregation and recruitment are controlled by nitric oxide (NO) generated by platelets and the endothelial cells. Derangements in this generation may contribute to the pathogenesis of thrombotic complications of vascular disorders. The pharmacologic supplementation of the diseased vasculature with drugs releasing NO may help to restore the hemostatic balance.
引用
收藏
页码：47 / 54
页数：8
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