Synthesis and Medicinal Properties of 2-deoxyribose and ribose C-Nucleosides

被引：42

作者：

Adamo, Mauro F. A. ^{[1
]}

Pergoli, Roberto ^{[1
]}

机构：

[1] Royal Coll Surgeons Ireland, Dept Pharmaceut & Med Chem, CSCB, Dublin 2, Ireland

来源：

CURRENT ORGANIC CHEMISTRY | 2008年 / 12卷 / 18期

关键词：

D O I：

10.2174/138527208786786318

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

C-nucleosides are important synthetic targets due to their potential as therapeutic agents and as biochemical probes. Nucleosides and nucleoside biochemistry lie at the heart of life and life propagation, and therefore nucleoside analogues have attracted much attention as anti-microbial and anti-cancer agents. In the recent past several groups reported their effort in the preparation of unnatural C-nucleosides based on deoxyribose and ribose. This review summarises the state of the art in the preparation of modified C-nucleosides and their medicinal properties.

引用

页码：1544 / 1569

页数：26

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