Primary progressive multiple sclerosis: progress and challenges

被引：46

作者：

Rice, Claire M. ^{[1
]}

Cottrell, David ^{[2
]}

Wilkins, Alastair ^{[3
]}

Scolding, Neil J. ^{[4
]}

机构：

[1] Univ Bristol, Inst Clin Neurosci, Frenchay Hosp, Bristol BS16 1LE, Avon, England

[2] North Bristol Trust, Frenchay Hosp, Dept Neurol, Bristol, Avon, England

[3] Univ Bristol, Dept Neurol, Frenchay Hosp, Bristol BS16 1LE, Avon, England

[4] Univ Bristol, Dept Neurol, Inst Clin Neurosci, Frenchay Hosp, Bristol BS16 1LE, Avon, England

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2013年 / 84卷 / 10期

关键词：

Multiple Sclerosis; MESENCHYMAL STEM-CELLS; HUMAN BONE-MARROW; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PLACEBO-CONTROLLED TRIAL; SPINAL-CORD-INJURY; STROMAL CELLS; FUNCTIONAL RECOVERY; DOUBLE-BLIND; NATURAL-HISTORY; OLIGODENDROCYTE PROGENITOR;

D O I：

10.1136/jnnp-2012-304140

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Primary progressive multiple sclerosis (MS) has long been recognised as presenting great difficulties to our management of what is increasingly a treatable neurological disease. Here we review some basic and clinical aspects of primary progressive MS, and describe how the disorder in fact offers powerful insights and opportunities for better understanding multiple sclerosis, and from a practical perspective an invaluable clinical substrate for studying and treating progressive disability in MS. Difficult hurdles remain, however, and these too are reviewed.

引用

页码：1100 / 1106

页数：7

共 107 条

[1] Remyelination of the spinal cord following intravenous delivery of bone marrow cells [J].

Akiyama, Y ;

Radtke, C ;

Honmou, O ;

Kocsis, JD .

GLIA, 2002, 39 (03) :229-236

[2]

Akiyama Y, 2002, J NEUROSCI, V22, P6623

[3]

Alves H, 2009, J CELL MOL MED

[4] Primary progressive multiple sclerosis: part of the MS disease spectrum or separate disease entity? [J].

Antel, Jack ;

Antel, Samson ;

Caramanos, Zografos ;

Arnold, Douglas L. ;

Kuhlmann, Tanja .

ACTA NEUROPATHOLOGICA, 2012, 123 (05) :627-638

[5] Human Bone Marrow-Derived Mesenchymal Stem Cells Induce Th2-Polarized Immune Response and Promote Endogenous Repair in Animal Models of Multiple Sclerosis [J].

Bai, Lianhua ;

Lennon, Donald P. ;

Eaton, Valerie ;

Maier, Kari ;

Caplan, Arnold I. ;

Miller, Stephen D. ;

Miller, Robert H. .

GLIA, 2009, 57 (11) :1192-1203

[6] CD133 Identifies a Human Bone Marrow Stem/Progenitor Cell Sub-population With a Repertoire of Secreted Factors That Protect Against Stroke [J].

Bakondi, Benjamin ;

Shimada, Issei S. ;

Perry, Anthony ;

Munoz, James R. ;

Ylostalo, Joni ;

Howard, Alan B. ;

Gregory, Carl A. ;

Spees, Jeffrey L. .

MOLECULAR THERAPY, 2009, 17 (11) :1938-1947

[7] Axonal protection using flecainide in experimental autoimmune encephalomyelitis [J].

Bechtold, DA ;

Kapoor, R ;

Smith, KJ .

ANNALS OF NEUROLOGY, 2004, 55 (05) :607-616

[8] The relationship between relapse, impairment and disability in multiple sclerosis [J].

Bennetto, L. ;

Burrow, J. ;

Sakai, H. ;

Cobby, J. ;

Robertson, N. P. ;

Scolding, N. .

MULTIPLE SCLEROSIS JOURNAL, 2011, 17 (10) :1218-1224

[9] Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE [J].

Black, Joel A. ;

Liu, Shujun ;

Hains, Bryan C. ;

Saab, Carl Y. ;

Waxman, Stephen G. .

BRAIN, 2006, 129 :3196-3208

[10] Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases [J].

Burt, Richard K. ;

Loh, Yvonne ;

Pearce, William ;

Beohar, Nirat ;

Barr, Walter G. ;

Craig, Robert ;

Wen, Yanting ;

Rapp, Jonathan A. ;

Kessler, John .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (08) :925-936

← 1 2 3 4 5 6 7 8 9 10 →