Developmentally degraded cortical temporal processing restored by training

被引:52
作者
Zhou, Xiaoming [1 ,2 ]
Merzenich, Michael M. [2 ]
机构
[1] E China Normal Univ, Sch Life Sci, Shanghai 200062, Peoples R China
[2] Univ Calif San Francisco, Dept Otolaryngol, Coleman Lab, WM Keck Ctr Integrat Neurosci, San Francisco, CA 94143 USA
基金
美国国家卫生研究院;
关键词
PRIMARY AUDITORY-CORTEX; IMPAIRED CHILDREN; CRITICAL PERIOD; PLASTICITY; MODULATION; DEFICITS;
D O I
10.1038/nn.2239
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Enduring deficits in temporal processing can be induced in the auditory cortex by rearing infant rats in the presence of low frequency-modulated noises. We found that it was possible to restore normal temporal processing, overcoming deficits induced during the critical period, by intensively training developmentally impaired animals as juveniles or young adults. Re-normalized cortical temporal response characteristics were sustained long after training cessation.
引用
收藏
页码:26 / 28
页数:3
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