Brain activation patterns in women with acquired hypoactive sexual desire disorder and women with normal sexual function: a cross-sectional pilot study

被引:30
作者
Woodard, Terri L. [1 ]
Nowak, Nicole T. [2 ]
Balon, Richard [3 ]
Tancer, Manuel [3 ]
Diamond, Michael P. [4 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA
[2] Univ Wisconsin, Dept Psychol, Milwaukee, WI 53201 USA
[3] Wayne State Univ, Sch Med, Dept Psychiat, Detroit, MI USA
[4] Georgia Regents Univ, Dept Obstet & Gynecol, Augusta, GA USA
基金
美国国家卫生研究院;
关键词
Brain activation patterns; female sexual dysfunction; functional neuroimaging; hypoactive sexual desire disorder (HSDD); sexual stimuli; POSITRON-EMISSION-TOMOGRAPHY; CEREBRAL-BLOOD-FLOW; PENILE ERECTION; EMOTIONAL EXPERIENCE; SENSORY STIMULATION; PREFRONTAL CORTEX; HUMAN MALES; AROUSAL; SELF; DYSFUNCTION;
D O I
10.1016/j.fertnstert.2013.05.041
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To examine and compare brain activation patterns of premenopausal women with normal sexual function and those with hypoactive sexual desire disorder (HSDD) during viewing of validated sexually explicit film clips. Design: Cross-sectional pilot study. Setting: University-based clinical research center. Patient(s): Premenopausal women. Intervention(s): None. Main Outcome Measure(s): Areas of brain activation during viewing of sexually explicit film clips. Result(s): Women with normal sexual function showed significantly greater activation of the right thalamus, left insula, left precentral gyrus, and left parahippocampal gyrus in comparison with women with HSDD, who exhibited greater activation of the right medial frontal gyrus and left precuneus regions. Conclusion(s): Women with HSDD may have alterations in activation of limbic and cortical structures responsible for acquiring, encoding, and retrieving memory, the processing and memory of emotional reactions, and areas responsible for heightened attention to one's own physical state. (Fertil Steril (R) 2013; 100: 1068-76. (C) 2013 by American Society for Reproductive Medicine.)
引用
收藏
页码:1068 / +
页数:14
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