ZIF Nanocrystal-Based Surface Acoustic Wave (SAW) Electronic Nose to Detect Diabetes in Human Breath

被引：38

作者：

Bahos, Fabio A. ^{[1
]}

Sainz-Vidal, Arianee ^{[1
]}

Sanchez-Perez, Celia ^{[1
]}

Saniger, Jose M. ^{[1
]}

Gracia, Isabel ^{[2
]}

Saniger-Alba, Maria M. ^{[3
]}

Matatagui, Daniel ^{[1
,4
]}

机构：

[1] Univ Nacl Autonoma Mexico, ICAT, Ciudad Univ, Mexico City 04510, DF, Mexico

[2] CSIC, IMB, Campus UAB, Bellaterra 08193, Spain

[3] Inst Nacl Nutr Salvador Zubiran, Dept Neurophysiol, Tlalpan 14080, Mexico

[4] CSIC, Inst Tecnol Fis & Informac ITEFI, SENSAVAN, Serrano 144, Madrid 28006, Spain

来源：

BIOSENSORS-BASEL | 2018年 / 9卷 / 01期

关键词：

eNose; gas sensor; SAW; surface acoustic wave; Love wave; diabetes; breath; VOC; ZIF; Zeolite; METAL-ORGANIC FRAMEWORK; ZEOLITIC IMIDAZOLATE FRAMEWORK; PLASMA-GLUCOSE; EXHALED BREATH; ACETONE; SENSORS; NANOPARTICLES; AMMONIA; ETHANOL; KETOSIS;

D O I：

10.3390/bios9010004

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In the present work, a novel, portable and innovative eNose composed of a surface acoustic wave (SAW) sensor array based on zeolitic imidazolate frameworks, ZIF-8 and ZIF-67 nanocrystals (pure and combined with gold nanoparticles), as sensitive layers has been tested as a non-invasive system to detect different disease markers, such as acetone, ethanol and ammonia, related to the diagnosis and control of diabetes mellitus through exhaled breath. The sensors have been prepared by spin coating, achieving continuous sensitive layers at the surface of the SAW device. Low concentrations (5 ppm, 10 ppm and 25 ppm) of the marker analytes were measured, obtaining high sensitivities, good reproducibility, short time response and fast signal recovery.

引用

页数：13

共 45 条

[1] Measuring airway exchange of endogenous acetone using a single-exhalation breathing maneuver [J].

Anderson, JC ;

Lamm, WJE ;

Hlastala, MP .

JOURNAL OF APPLIED PHYSIOLOGY, 2006, 100 (03) :880-889

[2]

Ballantine D.S., 1997, Acoustic Wave Sensors - Theory, Design, and Physico-Chemical Applications, P36, DOI [10.1016/B978-012077460-9/50003-4, DOI 10.1016/B978-012077460-9/50003-4]

[3] Zeolitic Imidazolate Framework as Formaldehyde Gas Sensor [J].

Chen, Er-Xia ;

Yang, Hui ;

Zhang, Jian .

INORGANIC CHEMISTRY, 2014, 53 (11) :5411-5413

[4] Cardiovascular Biomarkers in Exhaled Breath [J].

Cikach, Frank S., Jr. ;

Dweik, Raed A. .

PROGRESS IN CARDIOVASCULAR DISEASES, 2012, 55 (01) :34-43

[5] Metal oxide nanowire chemical sensors: innovation and quality of life [J].

Comini, Elisabetta .

MATERIALS TODAY, 2016, 19 (10) :559-567

[6] Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus [J].

Das, Souvik ;

Pal, Saurabh ;

Mitra, Madhuchhanda .

JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING, 2016, 36 (05) :605-624

[7] Zeolitic imidazolate framework-coated acoustic sensors for room temperature detection of carbon dioxide and methane [J].

Devkota, Jagannath ;

Kim, Ki-Joong ;

Ohodnicki, Paul R. ;

Culp, Jeffrey T. ;

Greve, David W. ;

Lekse, Jonathan W. .

NANOSCALE, 2018, 10 (17) :8075-8087

[8] Time variation of ammonia, acetone, isoprene and ethanol in breath: a quantitative SIFT-MS study over 30 days [J].

Diskin, AM ;

Spanel, P ;

Smith, D .

PHYSIOLOGICAL MEASUREMENT, 2003, 24 (01) :107-119

[9] Assembly of ZIF-67 Metal-Organic Framework over Tin Oxide Nanoparticles for Synergistic Chemiresistive CO2 Gas Sensing [J].

DMello, Marilyn Esclance ;

Sundaram, Nalini G. ;

Kalidindi, Suresh Babu .

CHEMISTRY-A EUROPEAN JOURNAL, 2018, 24 (37) :9220-9223

[10] Analysis of biogenic volatile organic compounds in human health and disease [J].

Dummer, Jack ;

Storer, Malina ;

Swanney, Maureen ;

McEwan, Murray ;

Scott-Thomas, Amy ;

Bhandari, Shrawan ;

Chambers, Stephen ;

Dweik, Raed ;

Epton, Michael .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2011, 30 (07) :960-967

← 1 2 3 4 5 →