Highly efficient divergent synthesis of dendrimers via metal-free "click" chemistry

被引:16
作者
Gonzaga, Ferdinand [1 ]
Sadowski, Lukas P. [1 ]
Rambarran, Talena [1 ]
Grande, John [1 ]
Adronov, Alex [1 ]
Brook, Michael A. [1 ]
机构
[1] McMaster Univ, Dept Chem & Chem Biol, W Hamilton, ON L8S 4M1, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
alkynes; azides; click chemistry; dendrimers; metal-free; monomers; synthesis; THIOL-ENE; CYCLOADDITION; MACROMOLECULES; CATALYSIS; POLYMERS; DESIGN; AZIDES;
D O I
10.1002/pola.26511
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
A new synthetic strategy to prepare dendrimers using a single, inexpensive monomer is described. Divergent growth relies on a highly efficient, metal-free Click cycloaddition of azides to alkynes. Functional dendrimers are obtained with minimal purification in high yields, with no by-product but a water soluble salt, and the excess of monomer used can be recycled at each stage of the iterative synthesis. © 2012 Wiley Periodicals, Inc.
引用
收藏
页码:1272 / 1277
页数:6
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