Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings

被引：32

作者：

Zhou, Kaixin ^{[1
]}

Asherson, Philip ^{[1
]}

Sham, Pak ^{[1
,2
]}

Franke, Barbara ^{[4
,5
]}

Anney, Richard J. L. ^{[3
]}

Buitelaar, Jan ^{[4
]}

Ebstein, Richard ^{[6
]}

Gill, Michael ^{[3
]}

Brookes, Keeley ^{[1
]}

Buschgens, Cathelijne ^{[4
]}

Campbell, Desmond ^{[1
]}

Chen, Wai ^{[1
]}

Christiansen, Hanna ^{[8
]}

Fliers, Ellen ^{[4
]}

Gabris, Isabel ^{[11
]}

Johansson, Lena

Marco, Rafaela ^{[12
]}

Mulas, Fernando ^{[13
]}

Mueller, Ueli ^{[15
]}

Mulligan, Aisling ^{[12
]}

Neale, Benjamin M. ^{[1
]}

Rijsdijk, Fruhling ^{[1
]}

Rommelse, Nanda ^{[14
]}

Uebel, Henrik ^{[9
]}

Psychogiou, Lamprini ^{[16
]}

Xu, Xiaohui ^{[1
]}

Banaschewski, Tobias ^{[9
,10
]}

Sonuga-Barke, Edmund J. S. ^{[1
,11
,16
,19
]}

Eisenberg, Jacques ^{[6
]}

Manor, Iris ^{[7
]}

Miranda, Ana ^{[3
]}

Oades, Robert D. ^{[8
]}

Roeyers, Herbert ^{[11
]}

Rothenberger, Aribert ^{[9
]}

Sergeant, Joseph ^{[14
]}

Steinhausen, Hans-Christoph ^{[15
]}

Taylor, Eric ^{[1
]}

Thompson, Margaret ^{[16
]}

Faraone, Stephen V. ^{[17
,18
]}

机构：

[1] Kings Coll London, MRC, Social Genet Dev & Psychiat Ctr, London WC2R 2LS, England

[2] Univ Hong Kong, LKS Fac Med, Dept Psychiat, Pokfulam, Hong Kong, Peoples R China

[3] St James Hosp, Trinity Ctr Hlth Sci, Dept Psychiat, Dublin 8, Ireland

[4] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, NL-6525 ED Nijmegen, Netherlands

[5] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands

[6] S Herzog Mem Hosp, Jerusalem, Israel

[7] Geha Mental Hlth Ctr, ADHD Clin, Petak Tikvah, Israel

[8] Univ Clin Child & Adolescent Psychiat, Essen, Germany

[9] Univ Gottingen, Gottingen, Germany

[10] Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, D-6800 Mannheim, Germany

[11] Univ Ghent, Dept Expt Clin Hlth Psychol, B-9000 Ghent, Belgium

[12] Univ Valencia, Dept Dev Educ Psychol, Valencia, Spain

[13] Univ Hosp La Fe, Neuropediat Serv, Valencia, Spain

[14] Vrije Univ Amsterdam, Dept Clin Neuropsychol, Amsterdam, Netherlands

[15] Univ Zurich, Dept Child & Adolescent Psychiat, Zurich, Switzerland

[16] Univ Southampton, Dept Psychol, Southampton SO9 5NH, Hants, England

[17] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY USA

[18] SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY USA

[19] NYU, Ctr Child Study, New York, NY USA

来源：

BIOLOGICAL PSYCHIATRY | 2008年 / 64卷 / 07期

基金：

美国国家卫生研究院;

关键词：

ADHD; linkage; QTL;

D O I：

10.1016/j.biopsych.2008.02.024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). Methods: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. Results: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p <.04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait. Conclusions: These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia.

引用

页码：571 / 576

页数：6

共 50 条

[1] Exclusion from School and Attention-Deficit/Hyperactivity Disorder
O'Regan, Fintan
INTERNATIONAL JOURNAL OF EMOTIONAL EDUCATION, 2010, 2 (02): : 3 - 18
[2] School Experiences of Adolescents With Attention-Deficit/Hyperactivity Disorder
Wiener, Judith
Daniels, Lesley
JOURNAL OF LEARNING DISABILITIES, 2016, 49 (06) : 567 - 581
[3] Association of Attention-Deficit/Hyperactivity Disorder with a Candidate Region for Reading Disabilities on Chromosome 6p
Couto, Jillian M.
Gomez, Lissette
Wigg, Karen
Ickowicz, Abel
Pathare, Tejaswee
Malone, Molly
Kennedy, James L.
Schachar, Russell
Barr, Cathy L.
BIOLOGICAL PSYCHIATRY, 2009, 66 (04) : 368 - 375
[4] School Readiness in Preschoolers With Symptoms of Attention-Deficit/Hyperactivity Disorder
Perrin, Hannah T.
Heller, Nicole A.
Loe, Irene M.
PEDIATRICS, 2019, 144 (02)
[5] Linkage of the dopamine receptor D1 gene to attention-deficit/hyperactivity disorder
Misener, VL
Luca, P
Azeke, O
Crosbie, J
Waldman, I
Tannock, R
Roberts, W
Malone, M
Schachar, R
Ickowicz, A
Kennedy, JL
Barr, CL
MOLECULAR PSYCHIATRY, 2004, 9 (05) : 500 - 509
[6] SCHOOL-BASED TREATMENT OF ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
Schultz, Brandon K.
Storer, Jennifer
Watabe, Yuko
Sadler, Joanna
Evans, Steven W.
PSYCHOLOGY IN THE SCHOOLS, 2011, 48 (03) : 254 - 262
[7] Attention-Deficit/Hyperactivity Disorder, School Performance, and Effect of Medication
Jangmo, Andreas
Stalhandske, Amanda
Chang, Zheng
Chen, Qi
Almqvist, Catarina
Feldman, Inna
Bulik, Cynthia M.
Lichtenstein, Paul
D'Onofrio, Brian
Kuja-Halkola, Ralf
Larsson, Henrik
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2019, 58 (04) : 423 - 432
[8] Linkage of the dopamine receptor D1 gene to attention-deficit/hyperactivity disorder
V L Misener
P Luca
O Azeke
J Crosbie
I Waldman
R Tannock
W Roberts
M Malone
R Schachar
A Ickowicz
J L Kennedy
C L Barr
Molecular Psychiatry, 2004, 9 : 500 - 509
[9] Testing the evolutionary advantage theory of attention-deficit/hyperactivity disorder traits
Arildskov, Trine Wigh
Virring, Anne
Thomsen, Per Hove
Ostergaard, Soren D.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 2022, 31 (02) : 337 - 348
[10] Testing the evolutionary advantage theory of attention-deficit/hyperactivity disorder traits
Trine Wigh Arildskov
Anne Virring
Per Hove Thomsen
Søren D. Østergaard
European Child & Adolescent Psychiatry, 2022, 31 : 337 - 348

← 1 2 3 4 5 →