Cascade Synthesis of Fenpiprane and Related Pharmaceuticals via Rhodium-Catalyzed Hydroaminomethylation

被引：35

作者：

Li, Shengkun ^{[1
,2
,3
]}

Huang, Kexuan ^{[2
,3
]}

Zhang, Jiwen ^{[1
]}

Wu, Wenjun ^{[1
]}

Zhang, Xumu ^{[2
,3
]}

机构：

[1] Northwest A&F Univ, Coll Sci, Yangling 712100, Shaanxi, Peoples R China

[2] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

[3] Rutgers State Univ, Dept Pharmaceut Chem, Piscataway, NJ 08854 USA

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 05期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

HIGHLY REGIOSELECTIVE HYDROFORMYLATION; INTERNAL OLEFINS; ISOMERIZATION-HYDROFORMYLATION; DICATIONIC ELECTROPHILES; COMPLEXES; LIGANDS; AMINES;

D O I：

10.1021/ol303483t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel rhodium catalytic system with Naphos as ligand was developed for an efficient hydroaminomethylation of 1,1-diphenylethene under relatively mild conditions. This will allow for an atom-economic and environmentally benign synthesis of fenpiprane and related pharmaceuticals.

引用

页码：1036 / 1039

页数：4

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