Directing T cell differentiation and function with small molecule inhibitors

被引：12
作者：
Bruno, Ludovica [1 ]
Merkenschlager, Matthias [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, MRC Clin Sci Ctr, Lymphocyte Dev Grp, London, England
来源：
CELL CYCLE | 2008年 / 7卷 / 15期
基金：
英国医学研究理事会;
关键词：
regulatory T cell; signaling; differentiation; migration; homing;
D O I：
10.4161/cc.6444
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Regulatory T (Treg) cells that express the signature transcription factor Foxp3 safeguard against autoimmunity and immune pathology. Recent studies show that a signaling network with the components phosphatidyl inositol 3 kinase (PI3K), Akt, and the mammalian target of rapamycin (mTOR) regulates the de novo expression of Foxp3 in CD4 T cells. In addition to CD4 T cell differentiation, PI3K/Akt/mTOR signaling also controls T cell migration. Here we review the new data, consider their evolutionary context and discuss their potential implications for immunotherapy.
引用
收藏
页码：2296 / 2298
页数：3
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