Physical-chemical properties of cross-linked chitosan electrospun fiber mats

被引：50

作者：

Sencadas, V. ^{[1
]}

Correia, D. M. ^{[2
,3
]}

Ribeiro, C. ^{[1
]}

Moreira, S. ^{[4
]}

Botelho, G. ^{[3
]}

Gomez Ribelles, J. L. ^{[5
,6
]}

Lanceros-Mendez, S. ^{[1
,7
]}

机构：

[1] Univ Minho, Ctr Dept Fis, P-4710058 Braga, Portugal

[2] Escola Super Tecnol, Inst Politecn Cavado & Ave, P-4750810 Barcelos, Portugal

[3] Univ Minho, Ctr Quim, Dept Quim, P-4710057 Braga, Portugal

[4] Univ Minho, Ctr Biol Engn, IBB, P-4710057 Braga, Portugal

[5] Univ Politecn Valencia, Ctr Biomat & Tissue Engn, Valencia 46022, Spain

[6] Networking Res Ctr Bioengn Biomat & Nanomed CIBER, Valencia, Spain

[7] Int Iberian Nanotechnol Lab INL, P-4715330 Braga, Portugal

来源：

POLYMER TESTING | 2012年 / 31卷 / 08期

关键词：

Chitosan scaffolds; Electrospinning; Crystallinity; Biomaterials; Nanofibers; LINKING; CHITIN; DRUG; GLUTARALDEHYDE; DEACETYLATION; NANOFIBERS; SCAFFOLDS; MECHANISM; DELIVERY; H-1-NMR;

D O I：

10.1016/j.polymertesting.2012.07.010

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Chitosan fiber mats were successfully processed by electrospinning. The as-spun fiber mats were neutralized with ethanol and cross-linked with glutaraldehyde. A decrease of the fiber average diameter from 243 +/- 43 nm down to 215.53 nm was observed for the neutralized and cross-linking chitosan membrane. It was found that the processing conditions do not alter the initial deacetylation degree of the polymer. Polymer crystallinity index showed a decrease from 61% for the Protasan material down to 17% for the cross-linking fiber mats. A swelling index up to 1000% was observed for the cross-linked samples. Preliminary MC-3T3-E1 cell culture results showed good cell adhesion and proliferation in the cross-linked chitosan fiber mats. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1062 / 1069

页数：8

共 33 条

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