Microbial translocation in HIV infection: causes, consequences and treatment opportunities

被引：350

作者：

Sandler, Netanya G. ^{[1
]}

Douek, Daniel C. ^{[1
]}

机构：

[1] NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2012年 / 10卷 / 09期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; T-CELL-ACTIVATION; NONCIRRHOTIC PORTAL-HYPERTENSION; MUCOSAL IMMUNE RECONSTITUTION; INTESTINAL EPITHELIAL-CELLS; TUMOR-NECROSIS-FACTOR; TOLL-LIKE RECEPTORS; ANTIRETROVIRAL THERAPY; SOLUBLE CD14; DISEASE PROGRESSION;

D O I：

10.1038/nrmicro2848

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Systemic immune activation is increased in HIV-infected individuals, even in the setting of virus suppression with antiretroviral therapy. Although numerous factors may contribute, microbial products have recently emerged as potential drivers of this immune activation. In this Review, we describe the intestinal damage that occurs in HIV infection, the evidence for translocation of microbial products into the systemic circulation and the pathways by which these products activate the immune system. We also discuss novel therapies that disrupt the translocation of microbial products and the downstream effects of microbial translocation.

引用

页码：655 / 666

页数：12

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