The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression

被引：202

作者：

Burnstock, Geoffrey ^{[1
,2
,3
]}

Knight, Gillian E. ^{[1
]}

机构：

[1] UCL, Sch Med, Auton Neurosci Ctr, Rowland Hill St, London NW3 2PF, England

[2] Univ Melbourne, Dept Pharmacol & Therapeut, Melbourne, Vic, Australia

[3] Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia

来源：

PURINERGIC SIGNALLING | 2018年 / 14卷 / 01期

关键词：

Pain; Infection; Cancer; CNS disorders; Cardiovascular; Airways; Diabetes; Kidney; Bladder; Liver; Gut; Immune cells; BRILLIANT BLUE G; TYPE-2; DIABETIC-RATS; P2X(7) RECEPTOR; PURINERGIC RECEPTORS; EXTRACELLULAR ATP; MOUSE MODEL; NLRP3; INFLAMMASOME; IN-VIVO; CELL INVASION; ANIMAL-MODEL;

D O I：

10.1007/s11302-017-9593-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised. P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular C terminus. Low concentrations of ATP open cation channels sometimes leading to cell proliferation, whereas high concentrations of ATP open large pores that release inflammatory cytokines and can lead to apoptotic cell death. Since many diseases involve inflammation and immune responses, and the P2X7R regulates inflammation, there has been recent interest in the pathophysiological roles of P2X7R and the potential of P2X7R antagonists to treat a variety of diseases. These include neurodegenerative diseases, psychiatric disorders, epilepsy and a number of diseases of peripheral organs, including the cardiovascular, airways, kidney, liver, bladder, skin and musculoskeletal. The potential of P2X7R drugs to treat tumour progression is discussed.

引用

页码：1 / 18

页数：18

共 224 条

[101] A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis [J].

Gu, Ben J. ;

Field, Judith ;

Dutertre, Sebastien ;

Ou, Amber ;

Kilpatrick, Trevor J. ;

Lechner-Scott, Jeannette ;

Scott, Rodney ;

Lea, Rodney ;

Taylor, Bruce V. ;

Stankovich, Jim ;

Butzkueven, Helmut ;

Gresle, Melissa ;

Laws, Simon M. ;

Petrou, Steven ;

Hoffjan, Sabine ;

Akkad, Denis A. ;

Graham, Colin A. ;

Hawkins, Stanley ;

Glaser, Anna ;

Bedri, Sahl Khalid ;

Hillert, Jan ;

Matute, Carlos ;

Antiguedad, Alfredo ;

Wiley, James S. .

HUMAN MOLECULAR GENETICS, 2015, 24 (19) :5644-5654

[102] ROLE OF THE PURINERGIC RECEPTOR P2XR4 AFTER BLUNT CHEST TRAUMA IN CIGARETTE SMOKE-EXPOSED MICE [J].

Hafner, Sebastian ;

Wagner, Katja ;

Weber, Sandra ;

Groeger, Michael ;

Wepler, Martin ;

McCook, Oscar ;

Scheuerle, Angelika ;

Stahl, Bettina ;

Huber-Lang, Markus ;

Jung, Birgit ;

Calzia, Enrico ;

Georgieff, Michael ;

Moeller, Peter ;

Frick, Manfred ;

Radermacher, Peter ;

Wagner, Florian .

SHOCK, 2017, 47 (02) :193-199

[103] Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7 [J].

Hashimoto-Hill, S. ;

Friesen, L. ;

Kim, M. ;

Kim, C. H. .

MUCOSAL IMMUNOLOGY, 2017, 10 (04) :912-923

[104] Feasibility study of B16 melanoma therapy using oxidized ATP to target purinergic receptor P2X7 [J].

Hattori, Fumie ;

Ohshima, Yasuhiro ;

Seki, Shizuka ;

Tsukimoto, Mitsutoshi ;

Sato, Mitsuru ;

Takenouchi, Takato ;

Suzuki, Akina ;

Takai, Erina ;

Kitani, Hiroshi ;

Harada, Hitoshi ;

Kojima, Shuji .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2012, 695 (1-3) :20-26

[105] Genetic and Pharmacological Inactivation of the Purinergic P2RX7 Receptor Dampens Inflammation but Increases Tumor Incidence in a Mouse Model of Colitis-Associated Cancer [J].

Hofman, Paul ;

Cherfils-Vicini, Julien ;

Bazin, Marie ;

Ilie, Marius ;

Juhel, Thierry ;

Hebuterne, Xavier ;

Gilson, Eric ;

Schmid-Alliana, Annie ;

Boyer, Olivier ;

Adriouch, Sahil ;

Vouret-Craviari, Valerie .

CANCER RESEARCH, 2015, 75 (05) :835-845

[106] P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice [J].

Hoque, Rafaz ;

Sohail, Muhammed Adnan ;

Salhanick, Steven ;

Malik, Ahsan F. ;

Ghani, Ayaz ;

Robson, Simon C. ;

Mehal, Wajahat Z. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2012, 302 (10) :G1171-G1179

[107] Blocking of the P2X7 receptor inhibits the activation of the MMP-13 and NF-κB pathways in the cartilage tissue of rats with osteoarthritis [J].

Hu, Hongbo ;

Yang, Baohui ;

Li, Yumin ;

Zhang, Subin ;

Li, Zheng .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2016, 38 (06) :1922-1932

[108] Extracellular ATP has stimulatory effects on the expression and release of IL-6 via purinergic receptors in normal human epidermal keratinocytes [J].

Inoue, Kaori ;

Hosoi, Junichi ;

Denda, Mitsuhiro .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 (02) :362-371

[109] Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor [J].

Iwata, Masaaki ;

Ota, Kristie T. ;

Li, Xiao-Yuan ;

Sakaue, Fumika ;

Li, Nanxin ;

Dutheil, Sophie ;

Banasr, Mounira ;

Duric, Vanja ;

Yamanashi, Takehiko ;

Kaneko, Koichi ;

Rasmussen, Kurt ;

Glasebrook, Andrew ;

Koester, Anja ;

Song, Dekun ;

Jones, Kenneth A. ;

Zorn, Stevin ;

Smagin, Gennady ;

Duman, Ronald S. .

BIOLOGICAL PSYCHIATRY, 2016, 80 (01) :12-22

[110] Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors [J].

Jelassi, Bilel ;

Anchelin, Monique ;

Chamouton, Julie ;

Luisa Cayuela, Maria ;

Clarysse, Lucie ;

Li, Junying ;

Gore, Jacques ;

Jiang, Lin-Hua ;

Roger, Sebastien .

CARCINOGENESIS, 2013, 34 (07) :1487-1496

← 6 7 8 9 10 11 12 13 14 15 →