Influence of hemodialysis on regadenoson clearance in an in vitro hemodialysis model

被引:3
作者
Gharibian, Katherine N. [1 ]
Murthy, Venkatesh L. [2 ,3 ]
Mueller, Bruce A. [4 ]
机构
[1] Med Coll Wisconsin, Sch Pharm, Milwaukee, WI 53226 USA
[2] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI USA
[3] Univ Michigan, Sch Med, Dept Radiol, Ann Arbor, MI USA
[4] Univ Michigan, Coll Pharm, Dept Clin Pharm, 428 Church St, Ann Arbor, MI 48109 USA
关键词
Regadenoson; chronic kidney disease (CKD); hemodialysis; clearance; CORONARY-ARTERY-DISEASE; STAGE RENAL-DISEASE; STRESS MYOCARDIAL-PERFUSION; AMERICAN-HEART-ASSOCIATION; SIDE-EFFECT PROFILE; REPLACEMENT THERAPY; KIDNEY-DISEASE; FLOW RESERVE; PHARMACOKINETICS; AMINOPHYLLINE;
D O I
10.1007/s12350-016-0667-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. Regadenoson is a novel pharmacological stress agent whose disposition during hemodialysis is not known. The purpose of this study was to determine the clearance of regadenoson under varying dialytic conditions using an in vitro hemodialysis model. Methods and Results. Whole human blood was used to analyze the effect of hemodialysis on the clearance of regadenoson. Regadenoson transmembrane clearance (CLD) was assessed for both a standard permeability and a high permeability polysulfone hemodialyzer with blood/ dialysate flow rates of 300/600 and 400/800 mL/min. A two-tailed, paired Student's t test was used to compare regadenoson CLD between hemodialyzer types and flow rates. The mean +/- SD regadenoson CLD values ranged between 62.5 +/- 11.8 and 89.1 +/- 24.0 mL/min for all dialytic conditions. There was no significant difference in regadenoson CLD between hemodialyzer types and flow rates (p >.05). Conclusions. Hemodialysis enhances the clearance of regadenoson independent of hemodialyzer permeability and blood/dialysate flow rate. This clearance is modest relative to total body clearance and is unlikely to produce a clinically significant outcome.
引用
收藏
页码:234 / 239
页数:6
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