Cell therapy in vascularized composite allotransplantation

被引：16

作者：

Anggelia, Madonna Rica ^{[1
,4
,5
]}

Cheng, Hui-Yun ^{[1
]}

Lai, Ping-Chin ^{[2
]}

Hsieh, Yun-Huan ^{[3
]}

Lin, Chih-Hung ^{[1
,4
,5
]}

Lin, Cheng-Hung ^{[1
,4
,5
,6
]}

机构：

[1] Chang Gung Mem Hosp, Ctr Vascularized Composite Allotransplantat, Taoyuan, Taiwan

[2] China Med Univ Hosp, Kidney Inst, Taichung, Taiwan

[3] Epworth Eastern Hosp, Dept Plast & Reconstruct Surg, East Melbourne, Vic, Australia

[4] Chang Gung Mem Hosp, Dept Plast & Reconstruct Surg, Taoyuan, Taiwan

[5] Chang Gung Univ, Coll Med, Taoyuan, Taiwan

[6] Chang Gung Mem Hosp Linkou, Ctr Vascularized Composite Allotransplantat, Dept Plast & Reconstruct Surg, 5 Fusing St Gueishan, Taoyuan 333, Taiwan

来源：

BIOMEDICAL JOURNAL | 2022年 / 45卷 / 03期

关键词：

Vascularized composite allotransplantation; Clinical transplantation; Cell therapy; Stem cell; Immune cell; REGULATORY T-CELLS; MESENCHYMAL STEM-CELLS; BONE-MARROW; OPERATIONAL TOLERANCE; DENDRITIC CELLS; UPPER-EXTREMITY; RAT MODEL; TRANSPLANTATION; ALLOGRAFT; INDUCTION;

D O I：

10.1016/j.bj.2022.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Allograft rejection is one of the obstacles in achieving a successful vascularized composite allotransplantation (VCA). Treatments of graft rejection with lifelong immunosuppression (IS) subject the recipients to a lifelong risk of cancer development and opportunistic in-fections. Cell therapy has recently emerged as a promising strategy to modulate the im-mune system, minimize immunosuppressant drug dosages, and induce allograft tolerance. In this review, the recent works regarding the use of cell therapy to improve allograft outcomes are discussed. The current data supports the safety of cell therapy. The suitable type of cell therapy in allotransplantation is clinically dependent. Bone marrow cell ther-apy is more suitable for the induction phase, while other cell therapies are more feasible in either the induction or maintenance phase, or for salvage of allograft rejection. Immune cell therapy focuses on modulating the immune response, whereas stem cells may have an additional role in promoting structural regenerations, such as nerve regeneration. Source, frequency, dosage, and route of cell therapy delivery are also dependent on the specific need in the clinical setting.

引用

页码：454 / 464

页数：11

共 85 条

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