Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits

被引：141

作者：

Streit, WJ ^{[1
]}

Sparks, DL ^{[1
]}

机构：

[1] UNIV KENTUCKY,SANDERS BROWN CTR AGING,KENTUCKY STATE MED EXAMINERS PROGRAM,JUSTICE CABINET,LEXINGTON,KY 40536

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 1997年 / 75卷 / 02期

关键词：

Alzheimer's disease; aging; senile plaques; amyloid; high serum cholesterol; lectin staining;

D O I：

10.1007/s001090050097

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Activated microglial cells are concentrated in senile plaques characteristic of Alzheimer's disease, Such accumulations of activated microglia may contribute towards neurodegeneratiun via production of cytokines and free radicals. Studies suggesting a link between Alzheimer's disease and heart disease led us to study microglia immunohistochemically, using monoclonal antibody LN-3, in age-matched nondemented humans with and without heart disease. Using a qualitative staging system for assessing morphological changes occurring in microglia, we found higher microglial activation in the blains of subjects with heart disease than in those without it. Lectin histochemical examination of brains from rabbits maintained on a high-cholesterol diet also revealed increased microglial activation and leukocyte infiltration. Collectively our observations from humans and rabbits suggest that hypercholesterolemia and heart disease accelerate brain aging, and that the formation of senile plaques may be the end result of progressive microglial activation that occurs with aging.

引用

页码：130 / 138

页数：9

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