Promotion of cellular NAD+ anabolism:: Therapeutic potential for oxidative stress in ageing and Alzheimer's disease

被引：48

作者：

Braidy, Nady ^{[1
]}

Guillemin, Gilles ^{[1
,2
]}

Grant, Ross ^{[1
,3
]}

机构：

[1] Univ New S Wales, Fac Med, Sydney, NSW, Australia

[2] St Vincents Hosp, Ctr Immunol, Sydney, NSW 2010, Australia

[3] Sydney Adventist Hosp, Australasian Res Inst, Sydney, NSW, Australia

来源：

NEUROTOXICITY RESEARCH | 2008年 / 13卷 / 3-4期

关键词：

NAD(+); Alzheimer's disease; inflammation; neurodegeneration; oxidative stress; DNA repair;

D O I：

10.1007/BF03033501

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Oxidative imbalance is a prominent feature in Alzheimer's disease and ageing. Increased levels of reactive oxygen species (ROS) can result in disordered cellular metabolism due to lipid peroxidation, protein-cross linking, DNA damage and the depletion of nicotinamide adenine dinucleotide (NAD+). NAD+ is a ubiquitous pyridine nucleotide that plays an essential role in important biological reactions, from ATP production and secondary messenger signalling, to transcriptional regulation and DNA repair. Chronic oxidative stress may be associated with NAD+ depletion and a subsequent decrease in metabolic regulation and cell viability. Hence, therapies targeted toward maintaining intracellular NAD+ pools may prove efficacious in the protection of age-dependent cellular damage, in general, and neurodegeneration in chronic central nervous system inflammatory diseases such as Alzheimer's disease, in particular.

引用

页码：173 / 184

页数：12

共 108 条

[91] A POPULATION-BASED STUDY OF DEMENTIA IN 85-YEAR-OLDS [J].