Allergic Bronchopulmonary Aspergillosis

被引：43

作者：

Bains, Sonia N. ^{[2
]}

Judson, Marc A. ^{[1
]}

机构：

[1] Albany Med Coll, Dept Med, Div Pulm & Crit Care Med, Albany, NY 12206 USA

[2] Med Univ S Carolina, Div Pulm Crit Care Allergy & Sleep Med, Charleston, SC 29425 USA

来源：

CLINICS IN CHEST MEDICINE | 2012年 / 33卷 / 02期

关键词：

ABPA; Asthma; Cystic fibrosis; Bronchiectasis; ANTI-IGE ANTIBODY; CYSTIC-FIBROSIS; PULMONARY ASPERGILLOSIS; CLINICAL-SIGNIFICANCE; GENE-MUTATIONS; SERUM IGE; ITRACONAZOLE; SINUSITIS; ASTHMA; TRIAL;

D O I：

10.1016/j.ccm.2012.02.003

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Allergic bronchopulmonary aspergillosis (ABPA) is caused by an exaggerated T(H)2 response to the ubiquitous mold Aspergillus fumigatus. ABPA develops in a small fraction of patients with cystic fibrosis and asthma, suggesting that intrinsic host defects play a major role in disease susceptibility. This article reviews current understanding of the immunopathology, clinical and laboratory findings, and diagnosis and management of ABPA. It highlights clinical and laboratory clues to differentiate ABPA from cystic fibrosis and asthma, which are challenging given clinical and serologic similarities. A practical diagnostic algorithm and management scheme to aid in the treatment of these patients is outlined.

引用

页码：265 / +

页数：18

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