Cytotoxic Activity of New Phenolic Compounds from Vietnamese Caesalpinia sappan

被引：5
|
作者：
Tran Manh Hung [1 ,2 ]
Nguyen Xuan Hai [1 ]
Nguyen Trung Nhan [1 ]
Ton That Quang [1 ]
Tran Le Quan [1 ]
To Dao Cuong [2 ]
Nguyen Hai Dang [3 ]
Nguyen Tien Dat [3 ]
机构：
[1] Vietnam Natl Univ, Univ Sci, Fac Chem, Ho Chi Minh City, Vietnam
[2] Catholic Univ Daegu, Coll Pharm, Kyeongbuk 712702, South Korea
[3] Vietnam Acad Sci & Technol, Inst Marine Biochem, Hanoi, Vietnam
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2013年 / 77卷 / 12期
关键词：
Caesalpinia sappan; Leguminosae; caesalpiniaphenols; HL-60; apoptosis; ORAL-CANCER CELLS; ANTIINFLAMMATORY ACTIVITY; GROWTH-INHIBITION; HEME OXYGENASE-1; APOPTOSIS; HEARTWOOD; BRAZILIN; HOMOISOFLAVONOIDS; SAPPANCHALCONE; CONSTITUENTS;
D O I：
10.1271/bbb.130493
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new phenolic compounds, caesalpiniaphenols G-H (1 and 2), were isolated from Vietnamese Caesalpinia sappan heartwood. The chemical structures were established mainly by extensive spectroscopic studies and chemical evidence. Compounds 1 and 2 showed potent inhibitory activity against HL-60 cancer cell lines with respective IC50 values of 16.7 and 22.5 mu g/mL. Treating HL-60 cells with various concentrations of 1 resulted in growth inhibition and the induction of apoptosis.
引用
收藏
页码：2378 / 2382
页数：5
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