The physiological role of DC-SIGN: A tale of mice and men

被引：147

作者：

Garcia-Vallejo, Juan J. ^{[1
]}

van Kooyk, Yvette ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Mol Cell Biol & Immunol, NL-1081 BT Amsterdam, Netherlands

来源：

TRENDS IN IMMUNOLOGY | 2013年 / 34卷 / 10期

关键词：

DC-SIGN; animal models; pattern recognition receptors; antigen presentation; C-TYPE LECTIN; T-CELL RESPONSES; DENDRITIC CELLS; MOUSE DC; ENDOTHELIAL-CELLS; CUTTING EDGE; EXPRESSION; RECEPTOR; MACROPHAGES; ANTIGEN;

D O I：

10.1016/j.it.2013.03.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The innate immune receptor DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin) was discovered over a decade ago and was initially identified as a pattern recognition receptor. In addition to its ability to recognize a broad range of pathogen-derived ligands and self-glycoproteins, DC-SIGN also mediates intercellular adhesion, as well as antigen uptake and signaling, which is a functional hallmark of dendritic cells (DCs). Most research on DC-SIGN has relied on in vitro studies. The in vivo function of DC-SIGN is difficult to address, in part because there are eight genetic homologs in mice with no clear DC-SIGN ortholog. Here, we summarize the functions attributed to DC-SIGN based on in vitro data and discuss the limitations of available mouse models to uncover the physiological role of this receptor in vivo.

引用

页码：482 / 486

页数：5

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