Synthesis of Polysubstituted Analogues of the 4-Methyl-2-phenylquinoline

被引:2
作者
Al-Qahtani, A. A. [1 ]
Al-Turki, T. M. [1 ]
Khan, M. [1 ]
Mousa, A. A. [1 ]
Alkhathlan, H. Z. [1 ]
机构
[1] King Saud Univ, Coll Sci, Dept Chem, Riyadh 11451, Saudi Arabia
关键词
Quinolines; 2-Aminoacetophenone; 2-Hydroxyacetophenones; 2-(4-Methyl-2-quinolinyl)aniline; LUNASIA-AMARA BLANCO; ONE-POT SYNTHESIS; FRIEDLANDER SYNTHESIS; SUBSTITUTED QUINOLINES; ANTIMALARIAL ACTIVITY; ALKALOIDS; EFFICIENT; CYCLIZATION; INHIBITORS; 2-ARYLQUINOLINE;
D O I
10.14233/ajchem.2013.14253
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A simple and convenient synthetic method for the direct synthesis of a series of polysubstituted analogues of the putative antifungal agent 4-methyl-2-phenylquinoline, a mimic of the natural bioactive 4-methoxy-2-phenylquinoline is reported.
引用
收藏
页码:6055 / 6058
页数:4
相关论文
共 70 条
[1]   NEW CONJUGATED POLYANTHRAZOLINES CONTAINING THIOPHENE MOIETIES IN THE MAIN CHAIN [J].
AGRAWAL, AK ;
JENEKHE, SA .
MACROMOLECULES, 1991, 24 (25) :6806-6808
[2]   Cyclization of Hydrazones of 2-Acetyl-1-naphthol and 1-Acetyl-2-naphthol with Triphosgene. Synthesis of Spiro Naphthoxazine Dimers [J].
Al-Bogami, Abdullah Saad ;
Al-Majid, Abdullah Mohammed ;
Al-Saad, Mohammed Ali ;
Mousa, Ahmed Amine ;
Al-Mazroa, Sara Abdullah ;
Alkhathlan, Hamad Zaid .
MOLECULES, 2009, 14 (06) :2147-2159
[3]  
Ali M., 2007, CATAL COMMUN, V8, P1214
[4]   A one-pot synthesis of 1,3-benzoxazines [J].
Alkhathlan, HZ .
SYNTHETIC COMMUNICATIONS, 2004, 34 (01) :71-77
[5]   Synthesis of 4-alkoxy-4-methyl- and 4-alkoxy-4-fluoromethyl-1,3-benzoxazinones [J].
Alkhathlan, HZ .
TETRAHEDRON, 2003, 59 (41) :8163-8170
[6]  
Alkhathlan HZ, 2002, J CHEM RES, P473
[7]   Quinazoline, pyrazolo[1, 5-c]quinazoline and spiro quinazoline dimers from trhe reaction of 2-aminoacetophenone hydrazones with trophosgene [J].
Alkhathlan, HZ ;
Al-Saad, MA ;
Al-Hazimi, HM ;
Al-Farhan, KA ;
Mousa, AA .
JOURNAL OF CHEMICAL RESEARCH, 2002, (12) :587-588
[8]   Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities [J].
An, Zeng-Yun ;
Yan, Yi-Yong ;
Peng, Dan ;
Ou, Tian-Miao ;
Tan, Jia-Heng ;
Huang, Shi-Liang ;
An, Lin-Kun ;
Gu, Lian-Quan ;
Huang, Zhi-Shu .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (09) :3895-3903
[9]   Synthesis of functionalised quinolines through tandem addition/annulation reactions of β-(2-aminophenyl)-α,β-ynones [J].
Arcadi, A ;
Marinelli, F ;
Rossi, E .
TETRAHEDRON, 1999, 55 (46) :13233-13250
[10]   A new green approach to the Friedlander synthesis of quinolines [J].
Arcadi, A ;
Chiarini, M ;
Di Giuseppe, S ;
Marinelli, F .
SYNLETT, 2003, (02) :203-206