Overview of the Extranigral Aspects of Parkinson Disease

被引：130

作者：

Lim, Shen-Yang ^{[1
]}

Fox, Susan H. ^{[1
]}

Lang, Anthony E. ^{[1
]}

机构：

[1] Toronto Western Hosp, Movement Disorders Ctr, Toronto, ON M5T 2S8, Canada

来源：

ARCHIVES OF NEUROLOGY | 2009年 / 66卷 / 02期

关键词：

SLEEP BEHAVIOR DISORDER; LEWY-BODY DISEASE; OLFACTORY DYSFUNCTION; VISUAL HALLUCINATIONS; DEMENTIA; RISK; PATHOLOGY; DOPAMINE; LEVODOPA; ASSOCIATION;

D O I：

10.1001/archneurol.2008.561

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In recent years, there has been increasing recognition of the features of Parkinson disease that are not related to nigrostriatal dopamine deficiency. This review addresses selected clinical, anatomic, pathologic, and biochemical correlates of the early premotor symptoms of Parkinson disease, later nonmotor fluctuations, and advanced dopa-unresponsive motor and nonmotor features. The recognition of early features that predate classic motor symptoms will be important as effective neuroprotective therapy becomes available. Later-stage features often contribute markedly to disability and impaired quality of life and, therefore, represent an important future therapeutic challenge.

引用

页码：167 / 172

页数：6

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