Genotoxic effects of bisphenol A on somatic cells of female mice, alone and in combination with X-rays

被引：16

作者：

Gajowik, Aneta ^{[1
]}

Radzikowska, Joanna ^{[1
]}

Dobrzynska, Malgorzata M. ^{[1
]}

机构：

[1] Natl Inst Hyg, Natl Inst Publ Hlth, Dept Radiat Hyg & Radiobiol, PL-00791 Warsaw, Poland

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2013年 / 757卷 / 02期

关键词：

Comet assay; Micronucleus; Bisphenol A; X-ray; MOUSE BONE-MARROW; DNA-DAMAGE; IN-VITRO; COMET ASSAY; RADIATION; EXPOSURE; REPRODUCTION; ALTERS;

D O I：

10.1016/j.mrgentox.2013.07.006

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Bisphenol A (BPA), a monomer used in the manufacture of epoxy, polycarbonate, and polystyrene resins, is a xenoestrogen present in many consumer products. We investigated the effects of 2-week exposure to BPA, either alone or in combination with X-rays, on the induction of DNA damage in somatic cells of female mice in vivo. The micronucleus and alkaline comet assays were used to evaluate genotoxicity. BPA induced DNA strand breaks in lung cells but not in bone marrow lymphocytes, liver, kidney, or spleen cells. Induction of micronuclei was observed only in polychromatic reticulocytes of peripheral blood. Levels of damage following combination exposure to ionizing radiation plus BPA depended on tissue, assay, and time. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：120 / 124

页数：5

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