Clinical implications and treatment of dengue

被引:47
作者
Pooja, Chawla [1 ]
Amrita, Yadav [1 ]
Viney, Chawla [1 ]
机构
[1] BBDNITM, Fac Pharm Pharmaceut Chem, Lucknow 226028, Uttar Pradesh, India
关键词
Dengue; DHF; DSS; Aedes; Flavivirus; POLYMERASE-CHAIN-REACTION; RAPID IMMUNOCHROMATOGRAPHIC TEST; AEDES-AEGYPTI; VIRUS-INFECTION; CAPTURE ELISA; LARVICIDAL ACTIVITY; HEMORRHAGIC-FEVER; SHOCK SYNDROME; DIAGNOSIS; IGM;
D O I
10.1016/S1995-7645(14)60016-X
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Dengue is a common pathogenic disease often proving fatal, more commonly affecting the tropics. Aedes mosquito is the vector for this disease, and outbreaks of dengue often cause mass damage to life. The current review is an effort to present an insight into the causes, etiology, symptoms, transmission, diagnosis, major organs affected, mitigation and line of treatment of this disease with special emphasis on drugs of natural origin. The disease has a potential to spread as an endemic, often claiming several lives and thus requires concerted efforts to work out better treatment options. Traditional medicine offers an alternative solution and could be explored as a safer treatment option. Development of a successful vaccine and immunization technique largely remains a challenge and a better antiviral approach needs to be worked out to complement the supportive therapy. No single synthetic molecule has found to be wholly effective enough to offer curative control and the line of treatment mostly utilizes a combination of fluid replacement and antipyretics-analgesics like molecules to provide symptomatic relief.
引用
收藏
页码:169 / 178
页数:10
相关论文
共 95 条
[71]   DENGUE IN THE CARIBBEAN - VIRUS ISOLATION IN A MOSQUITO (AEDES-PSEUDOSCUTELLARIS) CELL-LINE [J].
RACE, MW ;
WILLIAMS, MC ;
AGOSTINI, CFM .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1979, 73 (01) :18-22
[72]   Dengue hemorrhagic fever and shock syndromes [J].
Ranjit, Suchitra ;
Kissoon, Niranjan .
PEDIATRIC CRITICAL CARE MEDICINE, 2011, 12 (01) :90-100
[73]  
Reiter P, 2010, EUROSURVEILLANCE, V15, P11
[74]   Dengue virus life cycle: viral and host factors modulating infectivity [J].
Rodenhuis-Zybert, Izabela A. ;
Wilschut, Jan ;
Smit, Jolanda M. .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2010, 67 (16) :2773-2786
[75]   PRIMER-DIRECTED ENZYMATIC AMPLIFICATION OF DNA WITH A THERMOSTABLE DNA-POLYMERASE [J].
SAIKI, RK ;
GELFAND, DH ;
STOFFEL, S ;
SCHARF, SJ ;
HIGUCHI, R ;
HORN, GT ;
MULLIS, KB ;
ERLICH, HA .
SCIENCE, 1988, 239 (4839) :487-491
[76]  
Samuel PP, 2006, INDIAN J MED RES, V123, P615
[77]   Evaluation of ELISA-based sero-diagnosis of dengue fever in travelers [J].
Schwartz, E ;
Mileguir, F ;
Grossman, Z ;
Mendelson, E .
JOURNAL OF CLINICAL VIROLOGY, 2000, 19 (03) :169-173
[78]  
Service M. W., 1992, Southeast Asian Journal of Tropical Medicine and Public Health, V23, P681
[79]  
Simadibrata Marcellus, 2012, Acta Med Indones, V44, P57
[80]  
Simmons CP, 2010, NEW ENGL J MED, V366, P1423