RHEUMATOID ARTHRITIS: Autoantibodies, citrullinated histones and initiation of synovitis

被引：5

作者：

Deane, Kevin D. ^{[1
]}

机构：

[1] Univ Colorado Denver, Sch Med, Div Rheumatol, Aurora, CO 80045 USA

来源：

NATURE REVIEWS RHEUMATOLOGY | 2015年 / 11卷 / 12期

关键词：

ARTHRALGIA;

D O I：

10.1038/nrrheum.2015.134

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In the development of rheumatoid arthritis, which factors govern the transition from systemic autoimmunity to synovitis? A study combining findings from human disease and animal models suggests that autoantibodies to neutrophil-derived citrullinated histone 2B are important for this transition; however, a 'second hit' involving intra-articular inflammation and citrullination could also be crucial to this process.

引用

页码：688 / 689

页数：2

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