Graphene oxide as a nanocarrier for loading and delivery of medicinal drugs and as a biosensor for detection of serum albumin

被引：42
作者：
Ni, Yongnian [1 ,2 ]
Zhang, Fangyuan [1 ]
Kokot, Serge [3 ]
机构：
[1] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China
[2] Nanchang Univ, Dept Chem, Nanchang 330031, Peoples R China
[3] Queensland Univ Technol, Fac Sci & Engn, Sch Chem Phys & Mech Engn, Brisbane, Qld 4001, Australia
来源：
ANALYTICA CHIMICA ACTA | 2013年 / 769卷
基金：
中国国家自然科学基金;
关键词：
Graphene oxide; Nano-carrier; Serum albumin; Fluorescence enhancement; Chemometrics; Biosensor; RESONANCE ENERGY-TRANSFER; CARBON NANOTUBES; FLUORESCENCE; BINDING; FUNCTIONALIZATION; NANOPARTICLES; DOXORUBICIN; FORCES; MODEL; FILMS;
D O I：
10.1016/j.aca.2013.01.038
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The interaction of graphene oxide (GO), a medicinal drug (10-hydroxy camptothecin (HCPT)), and bovine serum albumin (BSA) was investigated with the aim of developing a method for the analysis of serum albumin proteins. It was demonstrated that HCPT could be readily loaded onto GO via the, pi-pi stacking interaction, and the delivery of HCPT to BSA was improved in the presence of GO; this, in turn, facilitated the binding interaction of HCPT and BSA. Chemometrics methods, multivariate curve resolution-alternating least squares (MCR-ALS) and parallel factor analysis (PARAFAC), were applied to resolve spectral data, and this assisted in the elucidation of the above interaction. GO was found to enhance the fluorescence response of HCPT to BSA, and thus, a low cost fluorescence bio-sensing platform was developed for fluorescence-enhanced detection of BSA based on GO. The satisfactory analytical performance of this biosensor for BSA was attributed to the structure and electronic properties of GO. (C) 2013 Elsevier B.V. All rights reserved.
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收藏
页码：40 / 48
页数：9
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