New indices of ischemic heart disease and aging: Studies on the serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and soluble vascular cell adhesion molecule-1 (VCAM-1) in patients with hypercholesterolemia and ischemic heart disease

被引：119

作者：

Morisaki, N ^{[1
]}

Saito, I ^{[1
]}

Tamura, K ^{[1
]}

Tashiro, J ^{[1
]}

Masuda, M ^{[1
]}

Kanzaki, T ^{[1
]}

Watanabe, S ^{[1
]}

Masuda, Y ^{[1
]}

Saito, Y ^{[1
]}

机构：

[1] CHIBA UNIV,SCH MED,DEPT INTERNAL MED 3,CHUO KU,CHIBA 260,JAPAN

来源：

ATHEROSCLEROSIS | 1997年 / 131卷 / 01期

关键词：

intercellular adhesion molecule-1; vascular cell adhesion molecule-1; soluble adhesion molecules; ischemic heart disease; aging;

D O I：

10.1016/S0021-9150(97)06083-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is known that the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on the surface of vascular endothelial cells is closely related to the formation of early atherosclerotic lesions. In this study, serum soluble ICAM-1(sICAM-1) and soluble VCAM-1(sVCAM-1) were determined by sandwich ELISA both in normal healthy individuals (n = 114) and in patients with hypercholesterolemia (HC, n = 112) or ischemic heart disease (IHD, n = 38) to clarify the significance of the soluble forms of the adhesion molecules in the development of atherosclerotic diseases. IHD patients, not HC patients, showed significant elevation of sICAM-1, but not of sVCAM-1, compared with controls in age and sex-matched subjects. In addition, multiple linear regression analysis showed that sICAM-1 was correlated only to the presence of IHD but not to age and lipids. Multiple logistic regression analysis revealed that sICAM-1 was the most powerful independent predictor of the presence of IHD. On the other hand, sVCAM-1, not sICAM-1, was positively correlated to age. Multiple linear regression analysis showed that age was the most powerful independent predictor of the level of sVCAM-1. These data suggest that sICAM-1 and sVCAM-1 are useful as indices of clinical manifestations of atherosclerosis and aging, respectively. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：43 / 48

页数：6

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