Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation

被引:8
作者
Suzuki, Akane S. [1 ]
Yagi, Ryoji [2 ]
Kimura, Motoko Y. [2 ]
Iwamura, Chiaki [2 ]
Shinoda, Kenta [2 ]
Onodera, Atsushi [2 ,3 ]
Hirahara, Kiyoshi [2 ]
Tumes, Damon J. [2 ,4 ,5 ]
Koyama-Nasu, Ryo [2 ]
Iismaa, Siiri E. [6 ]
Graham, Robert M. [6 ]
Motohashi, Shinichiro [1 ]
Nakayama, Toshinori [2 ]
机构
[1] Chiba Univ, Grad Sch Med, Dept Med Immunol, Chiba, Japan
[2] Chiba Univ, Grad Sch Med, Dept Immunol, Chiba, Japan
[3] Chiba Univ, Inst Global Prominent Res, Chiba, Japan
[4] SA Pathol, Ctr Canc Biol, Adelaide, SA, Australia
[5] Univ South Australia, Adelaide, SA, Australia
[6] Victor Chang Cardiac Res Inst, Mol Cardiol & Biophys Div, Sydney, NSW, Australia
来源
FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷
关键词
TG2; CD30; memory Th cell generation; Th17; Th1; memory precursor; airway inflammation; CD4(+) T-CELLS; CROSS-LINKING; EFFECTOR; TRANSGLUTAMINASE; DIFFERENTIATION; MAINTENANCE; RESPONSES; PLASTICITY; CD30; INFLAMMATION;
D O I
10.3389/fimmu.2020.01536
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Memory helper T (Th) cells are crucial for secondary immune responses against infectious microorganisms but also drive the pathogenesis of chronic inflammatory diseases. Therefore, it is of fundamental importance to understand how memory T cells are generated. However, the molecular mechanisms governing memory Th cell generation remain incompletely understood. Here, we identified CD30 as a molecule heterogeneously expressed on effector Th1 and Th17 cells, and CD30(hi)effector Th1 and Th17 cells preferentially generated memory Th1 and Th17 cells. We found that CD30 mediated signal induced Transglutaminase-2 (TG2) expression, and that the TG2 expression in effector Th cells is essential for memory Th cell generation. In fact,Cd30-deficiency resulted in the impaired generation of memory Th1 and Th17 cells, which can be rescued by overexpression of TG2. Furthermore,transglutaminase-2(Tgm2)-deficient CD4 T cells failed to become memory Th cells. As a result, T cells fromTgm2-deficient mice displayed impaired antigen-specific antibody production and attenuated Th17-mediated allergic responses. Our data indicate that CD30-induced TG2 expression in effector Th cells is essential for the generation of memory Th1 and Th17 cells, and that CD30 can be a marker for precursors of memory Th1 and Th17 cells.
引用
收藏
页数:12
相关论文
共 50 条
[41]   Circulating Th1, Th2, Th9, Th17, Th22, and Treg Levels in Aortic Dissection Patients [J].
Ye, Jing ;
Wang, Yuan ;
Wang, Zhen ;
Ji, Qingwei ;
Huang, Ying ;
Zeng, Tao ;
Hu, Haiying ;
Ye, Di ;
Wan, Jun ;
Lin, Yingzhong .
MEDIATORS OF INFLAMMATION, 2018, 2018
[42]   TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression [J].
Liu, Hou-Pu ;
Cao, Anthony T. ;
Feng, Ting ;
Li, Qingjie ;
Zhang, Wenbo ;
Yao, Suxia ;
Dann, Sara M. ;
Elson, Charles O. ;
Cong, Yingzi .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2015, 45 (04) :1010-1018
[43]   Neointimal myofibroblasts contribute to maintaining Th1/Tc1 and Th17/ Tc17 inflammation in giant cell arteritis [J].
Greigert, Helene ;
Ramon, Andre ;
Genet, Coraline ;
Cladiere, Claudie ;
Gerard, Claire ;
Cuidad, Marion ;
Corbera-Bellalta, Marc ;
Alba-Rovira, Roser ;
Arnould, Louis ;
Creuzot-Garcher, Catherine ;
Martin, Laurent ;
Tarris, Georges ;
Ghesquiere, Thibault ;
Ouandji, Sethi ;
Audia, Sylvain ;
Cid, Maria C. ;
Bonnotte, Bernard ;
Samson, Maxime .
JOURNAL OF AUTOIMMUNITY, 2024, 142
[44]   Dupilumab-associated ocular surface disease is characterized by a shift from Th2/Th17 toward Th1/Th17 inflammation [J].
Thormann, Kathrin ;
Luethi, Anne-Sophie ;
Deniau, Felix ;
Heider, Anja ;
Cazzaniga, Simone ;
Radonjic-Hoesli, Susanne ;
Lehmann, Mathias ;
Schlapbach, Christoph ;
Herzog, Elio L. ;
Kreuzer, Marco ;
Zinkernagel, Martin S. ;
Akdis, Cezmi A. ;
Zysset-Burri, Denise C. ;
Simon, Hans-Uwe ;
Simon, Dagmar .
ALLERGY, 2024, 79 (04) :937-948
[45]   Role of Th17 Cell in Tubercle Bacillus Infection [J].
Zhang, Dandan .
2017 3RD INTERNATIONAL CONFERENCE ON ENVIRONMENTAL SCIENCE AND MATERIAL APPLICATION (ESMA2017), VOLS 1-4, 2018, 108
[46]   A critical role for Th17 cell-derived TGF-β1 in regulating the stability and pathogenicity of autoimmune Th17 cells [J].
Choi, Garam ;
Park, Young-Jun ;
Cho, Minkyoung ;
Moon, Heesu ;
Kim, Daehong ;
Kang, Chang-Yuil ;
Chung, Yeonseok ;
Kim, Byung-Seok .
EXPERIMENTAL AND MOLECULAR MEDICINE, 2021, 53 (05) :993-1004
[47]   Human Blood CD1c+ Dendritic Cells Promote Th1 and Th17 Effector Function in Memory CD4+ T Cells [J].
Rojas, Ingrid M. Leal ;
Mok, Wai-Hong ;
Pearson, Frances E. ;
Minoda, Yoshihito ;
Kenna, Tony J. ;
Barnard, Ross T. ;
Radford, Kristen J. .
FRONTIERS IN IMMUNOLOGY, 2017, 8
[48]   Effect of type 2 diabetes mellitus and periodontitis on the Th1/Th2 and Th17/Treg paradigm [J].
Li, Jinfeng ;
Wang, Jia ;
Song, Xiangxin ;
Li, Zhiwei ;
Zhang, Yanjun ;
Lu, Hao ;
Chen, Xiaotao .
AMERICAN JOURNAL OF DENTISTRY, 2022, 35 (01) :55-60
[49]   IFN-γ and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells [J].
Lexberg, Maria H. ;
Taubner, Annegret ;
Albrecht, Inka ;
Lepenies, Inga ;
Richter, Anne ;
Kamradt, Thomas ;
Radbruch, Andreas ;
Chang, Hyun-Dong .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, 40 (11) :3017-3027
[50]   Regulation of Th1 and Th17 Cell Differentiation and Amelioration of Experimental Autoimmune Encephalomyelitis by Natural Product Compound Berberine [J].
Qin, Xia ;
Guo, Bingshi T. ;
Wan, Bing ;
Fang, Lei ;
Lu, Limin ;
Wu, Lili ;
Zang, Ying Qin ;
Zhang, Jingwu Z. .
JOURNAL OF IMMUNOLOGY, 2010, 185 (03) :1855-1863