Biocompatible nanocomposite of carboxymethyl cellulose and functionalized carbon-norfloxacin intercalated layered double hydroxides

被引：51

作者：

Allou, N'guadi Blaise ^{[1
,2
]}

Yadav, Archana ^{[3
]}

Pal, Mintu ^{[2
,3
]}

Goswamee, Rajib Lochan ^{[1
,2
]}

机构：

[1] CSIR, NEIST, Mat Sci & Technol Div, Adv Mat Grp, Jorhat 785006, Assam, India

[2] Acad Sci & Innovat Res, Jorhat Campus, Jorhat, Assam, India

[3] CSIR, NEIST, Biol Sci & Technol Div, Biotechnol Grp, Jorhat 785006, Assam, India

来源：

CARBOHYDRATE POLYMERS | 2018年 / 186卷

关键词：

Layered double hydroxides; Sodium carboxymethyl cellulose; Functionalized carbon; Citric acid cross-linking; Norfloxacin; Controlled release; DRUG-DELIVERY SYSTEM; ANTIBIOFILM ACTIVITY; THERMAL-STABILITY; ANTICANCER DRUGS; RELEASE PROPERTY; COMPOSITE FILMS; NANOPARTICLES; CYTOTOXICITY; NANOSHEETS;

D O I：

10.1016/j.carbpol.2018.01.066

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In recent years, the development of systems with progressive drug release properties, which is an effective technique for the use of drugs, has aroused great interest in the field of controlled release formulations. In this work, hybrid materials containing citric acid cross-linked carboxymethyl cellulose (CMC) and norfloxacin (NOR) intercalated layered double hydroxide (LDH) deposited over the surface of functionalized carbon (AC) were prepared. The synthesized CMC@AC-LDHeNOR nanohybrids were characterized using different techniques and in vitro NOR release behaviors were investigated in phosphate buffer saline, pH 7.4 at 37 degrees C. On the basis of the release profiles, it was found that NOR release was delayed when it was intercalated in AC-LDH which in presence of modified CMC decreases further. The nanohybrids indicated enhancement of antibacterial activity against gram-negative and gram-positive bacteria. The MTT assay showed their non-toxic behavior against ovarian normal epithelial and cancer cells, suggesting their potential use as drug carriers.

引用

页码：282 / 289

页数：8