Non-invasive assessment of airway inflammation in occupational lung diseases

被引:16
作者
Lemiere, Catherine [1 ]
机构
[1] Univ Montreal, Sacre Coeur Hosp, Dept Chest Med, Montreal, PQ, Canada
关键词
D O I
10.1097/00130832-200204000-00005
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The clinical investigation of occupational asthma is currently based on the demonstration of functional changes after exposure to occupational agents, but it does not yet include any monitoring of airway inflammation, one of the hallmarks of this disease. Methods permitting a non-invasive assessment of airway inflammation, such as induced sputum and exhaled nitric oxide, are currently under investigation for research purposes in occupational asthma. Their role in clinical practice has not yet been established. The advantages and limitations of these methods for occupational airway diseases, and more particularly occupational asthma, are discussed in this review. (C) 2002 Lippincott Williams & Wilkins.
引用
收藏
页码:109 / 114
页数:6
相关论文
共 39 条
[11]   A RESEARCH METHOD TO INDUCE AND EXAMINE A MILD EXACERBATION OF ASTHMA BY WITHDRAWAL OF INHALED CORTICOSTEROID [J].
GIBSON, PG ;
WONG, BJO ;
HEPPERLE, MJE ;
KLINE, PA ;
GIRGISGABARDO, A ;
GUYATT, G ;
DOLOVICH, J ;
DENBURG, JA ;
RAMSDALE, EH ;
HARGREAVE, FE .
CLINICAL AND EXPERIMENTAL ALLERGY, 1992, 22 (05) :525-532
[12]   INDUCTION OF NITRIC-OXIDE SYNTHASE IN ASTHMA [J].
HAMID, Q ;
SPRINGALL, DR ;
RIVEROSMORENO, V ;
CHANEZ, P ;
HOWARTH, P ;
REDINGTON, A ;
BOUSQUET, J ;
GODARD, P ;
HOLGATE, S ;
POLAK, JM .
LANCET, 1993, 342 (8886-7) :1510-1513
[13]   Changes in sputum eosinophils predict less of asthma control [J].
Jatakanon, A ;
Lim, S ;
Barnes, PJ .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (01) :64-72
[14]   ALLERGEN-INDUCED LATE ASTHMATIC REACTIONS ARE ASSOCIATED WITH ELEVATION OF EXHALED NITRIC-OXIDE [J].
KHARITONOV, SA ;
OCONNOR, BJ ;
EVANS, DJ ;
BARNES, PJ .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1995, 151 (06) :1894-1899
[15]   Airway reactivity and exhaled NO following swine dust exposure in healthy volunteers [J].
Kölbeck, KG ;
Ehnhage, A ;
Juto, JE ;
Forsberg, S ;
Gyllenhammar, H ;
Palmberg, L ;
Larsson, K .
RESPIRATORY MEDICINE, 2000, 94 (11) :1065-1072
[16]  
Leigh R, 1999, Can Respir J, V6, P194
[17]   Occupational eosinophilic bronchitis without asthma:: An unknown occupational airway disease [J].
Lemière, C ;
Efthimiadis, A ;
Hargreave, FE .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1997, 100 (06) :852-853
[18]   Differential cell counts in sputum in respiratory epidemiology -: A pilot study [J].
Lemière, C ;
Walker, C ;
O'Shaughnessy, D ;
Efthimiadis, A ;
Hargreave, FE ;
Sears, MR .
CHEST, 2001, 120 (04) :1107-1113
[19]   Changes in sputum cell counts after exposure to occupational agents:: What do they mean? [J].
Lemière, C ;
Chaboillez, S ;
Malo, JL ;
Cartier, A .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (06) :1063-1068
[20]  
Lemière C, 2000, J ALLERGY CLIN IMMUN, V106, P1163