Immunodiagnostic Methods: What Is Their Role in Areas of Low Endemicity?

被引：12

作者：

Queiroz Grenfell, Rafaella Fortini ^{[1
]}

Silva-Moraes, Vanessa ^{[1
]}

Taboada, Diana ^{[1
]}

Alves de Mattos, Ana Carolina ^{[1
]}

Sarvel de Castro, Ana Karine ^{[1
]}

Zech Coelho, Paulo Marcos ^{[1
]}

机构：

[1] Oswaldo Cruz Fdn Fiocruz, Schistosomiasis Lab, Rene Rachou Res Ctr, BR-1715201 Belo Horizonte, MG, Brazil

来源：

SCIENTIFIC WORLD JOURNAL | 2012年

关键词：

SCHISTOSOMA-MANSONI INFECTION; LOW-TRANSMISSION; DIAGNOSIS; ANTIGENS; STATE; METAANALYSIS; ELISA; SERUM; ASSAY;

D O I：

10.1100/2012/593947

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Worldwide Schistosomiasis mansoni continues to be a serious public health problem. Over the past decades, control programmes have made remarkable progress in reducing S. mansoni infections to a relatively low level in Brazil and African countries. Endemic regions are currently circumscribed in certain core areas where reinfection and repeated chemotherapy are frequent and, consequently, are related to residents with low parasite load. At present, diagnosis is predominately a key step for final disease control although low endemicity area residents are hardly detected by most of the available assays. In this paper, we review the current status and efforts made aiming at the improvement of diagnostic tools for S. mansoni in low endemicity infections. The establishment of diagnostic assays-simple, affordable, sensitive, and specific for field diagnosis of S. mansoni-is essential and should be given high priority.

引用

页数：5

共 46 条

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