The Antiobesity Effect of Polygonum aviculare L. Ethanol Extract in High-Fat Diet-Induced Obese Mice

被引：30
作者：
Sung, Yoon-Young [1 ]
Yoon, Taesook [1 ]
Yang, Won-Kyung [1 ]
Kim, Seung Ju [1 ]
Kim, Dong-Seon [1 ]
Kim, Ho Kyoung [1 ,2 ]
机构：
[1] Korea Inst Oriental Med, Basic Herbal Med Res Grp, Taejon 305811, South Korea
[2] Korea Inst Oriental Med, Herbal Mat Management Team, Taejon 305811, South Korea
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2013年 / 2013卷
关键词：
ORIENTAL HERBAL MEDICINE; PPAR-GAMMA; ANTIOXIDANT ACTIVITY; LIPID-METABOLISM; ADIPOSE-TISSUE; GLUCOSE; BOFUTSUSHOSAN; ADIPOCYTES; QUERCETIN; IMPROVES;
D O I：
10.1155/2013/626397
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
The antiobesity effects of a P. aviculare ethanol extract (PAE) in high-fat diet- (HFD-) induced obese mice were investigated. The mice were fed an HFD or an HFD supplemented with PAE (400 mg/kg/day) for 6.5 weeks. The increased body weights, adipose tissue weight, and adipocyte area as well as serum total triglyceride, leptin, and malondialdehyde concentrations were decreased in PAE-treated HFD-induced obese mice relative to the same measurements in untreated obese mice. Furthermore, PAE significantly suppressed the elevated mRNA expression levels of sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma, fatty acid synthase, and adipocyte protein 2 in the white adipose tissue of obese mice. In addition, PAE treatment of 3T3-L1 cells inhibited adipocyte differentiation and fat accumulation in a dose-dependent manner. These results suggest that PAE exerts antiobesity effects in HFD-induced obese mice through the suppression of lipogenesis in adipose tissue and increased antioxidant activity.
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页数：11
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