DNA Repair by Reversal of DNA Damage

被引：95
作者：
Yi, Chengqi [1 ,2 ]
He, Chuan [3 ,4 ]
机构：
[1] Peking Univ, State Key Lab Prot & Plant Gene Res, Sch Life Sci, Beijing 100871, Peoples R China
[2] Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
[3] Univ Chicago, Dept Chem, Chicago, IL 60637 USA
[4] Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USA
来源：
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2013年 / 5卷 / 01期
关键词：
HUMAN ALKB HOMOLOG; NUCLEOTIDE EXCISION-REPAIR; SINGLE-STRANDED-DNA; HUMAN O-6-ALKYLGUANINE-DNA ALKYLTRANSFERASE; TEMOZOLOMIDE PLUS O-6-BENZYLGUANINE; CHEMICAL CROSS-LINKING; COLI ADAPTIVE RESPONSE; OBESITY-ASSOCIATED FTO; ESCHERICHIA-COLI; TRANSFER-RNA;
D O I：
10.1101/cshperspect.a012575
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Endogenous and exogenous factors constantly challenge cellular DNA, generating cytotoxic and/or mutagenic DNA adducts. As a result, organisms have evolved different mechanisms to defend against the deleterious effects of DNA damage. Among these diverse repair pathways, direct DNA-repair systems provide cells with simple yet efficient solutions to reverse covalent DNA adducts. In this review, we focus on recent advances in the field of direct DNA repair, namely, photolyase-, alkyltransferase-, and dioxygenase-mediated repair processes. We present specific examples to describe new findings of known enzymes and appealing discoveries of new proteins. At the end of this article, we also briefly discuss the influence of direct DNA repair on other fields of biology and its implication on the discovery of new biology.
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页数：18
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