Analysis of the Genetic Basis of Disease in the Context of Worldwide Human Relationships and Migration

被引：57

作者：

Corona, Erik ^{[1
,2
,3
]}

Chen, Rong ^{[1
,3
]}

Sikora, Martin ^{[4
]}

Morgan, Alexander A. ^{[1
,2
]}

Patel, Chirag J. ^{[1
,2
,3
]}

Ramesh, Aditya ^{[1
,3
]}

Bustamante, Carlos D. ^{[4
]}

Butte, Atul J. ^{[1
,2
,3
]}

机构：

[1] Stanford Univ, Dept Pediat, Div Syst Med, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Program Biomed Informat, Sch Med, Stanford, CA 94305 USA

[3] Lucile Packard Childrens Hosp, Palo Alto, CA USA

[4] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA

来源：

PLOS GENETICS | 2013年 / 9卷 / 05期

基金：

美国国家科学基金会;

关键词：

GENOME-WIDE ASSOCIATION; POPULATION; COMMON; VARIANTS; RISK; ADAPTATIONS; FREQUENCY; SELECTION; PATTERNS; INDIANS;

D O I：

10.1371/journal.pgen.1003447

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genetic diversity across different human populations can enhance understanding of the genetic basis of disease. We calculated the genetic risk of 102 diseases in 1,043 unrelated individuals across 51 populations of the Human Genome Diversity Panel. We found that genetic risk for type 2 diabetes and pancreatic cancer decreased as humans migrated toward East Asia. In addition, biliary liver cirrhosis, alopecia areata, bladder cancer, inflammatory bowel disease, membranous nephropathy, systemic lupus erythematosus, systemic sclerosis, ulcerative colitis, and vitiligo have undergone genetic risk differentiation. This analysis represents a large-scale attempt to characterize genetic risk differentiation in the context of migration. We anticipate that our findings will enable detailed analysis pertaining to the driving forces behind genetic risk differentiation.

引用

页数：13

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