BRAIN-GUT AND APPETITE REGULATING HORMONES IN THE CONTROL OF GASTRIC SECRETION AND MUCOSAL PROTECTION

被引：0

作者：

Konturek, S. J. ^{[1
]}

Brzozowski, T. ^{[1
]}

Konturek, P. C. ^{[2
]}

Schubert, M. L. ^{[3
]}

Pawlik, W. W. ^{[1
]}

Padol, S. ^{[1
]}

Bayner, J. ^{[1
]}

机构：

[1] Jagiellonian Univ, Coll Med, Dept Clin Physiol, PL-31531 Krakow, Poland

[2] Univ Erlangen Nurnberg, Dept Med 1, Erlangen, Germany

[3] Virginia Commonwealth Univ, Med Coll Virginia, Richmond, VA 23298 USA

来源：

JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2008年 / 59卷

关键词：

gastric acid; mucosal damage; gastroprotection; vagal nerves; gastrin; ghrelin; leptin; melatonin;

D O I：

暂无

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The progress in basic and clinical gastrology indicates that gastric mucosal integrity represents a balance between offensive and defensive factors, The main offensive factors appear to be gastric acid and pepsin under health conditions, while the nonsteroidal anti-inflammatory drugs (NSAID) and Helicobacter pylori (H. pylori), infecting this mucosa, are currently considered the most important "aggressive" factors under pathological conditions. To the list of the aggressive factors, also stress, certain cytokines (TNF-alpha, IL-8, IL-11 and IL-18) and oxygen or nitrogen free radicals should be added. The aims of this review is the presentation of the involvement of aggressive and protective factors in the control of gastric acid secretion and appetite regulating hormones in maintaining gastric mucosal integrity and its protection against damaging factors.

引用

页码：7 / 31

页数：25

共 69 条

[41] CHOLECYSTOKININ RECEPTOR ANTAGONIST MK-329 BLOCKS INTESTINAL FAT-INDUCED INHIBITION OF MEAL-STIMULATED GASTRIC-ACID SECRETION [J].

LLOYD, KCK ;

MAXWELL, V ;

KOVACS, TOG ;

MILLER, J ;

WALSH, JH .

GASTROENTEROLOGY, 1992, 102 (01) :131-138

[42] CALCITONIN-GENE-RELATED PEPTIDE MODULATES ACID-MEDIATED REGULATION OF SOMATOSTATIN AND GASTRIN-RELEASE FROM RAT ANTRUM [J].

MANELA, FD ;

REN, JY ;

GAO, JS ;

MCGUIGAN, JE ;

HARTY, RF .

GASTROENTEROLOGY, 1995, 109 (03) :701-706

[43] Synergy between leptin and cholecystokinin (CCK) to control daily caloric intake [J].

Matson, CA ;

Wiater, MF ;

Kuijper, JL ;

Weigle, DS .

PEPTIDES, 1997, 18 (08) :1275-1278

[44]

MERCER DW, 1996, AM J PHYSIOL, V27, P692

[45] Histamine H3-receptor antagonists inhibit gastroprotection by (R)-α-methylhistamine in the rat [J].

Morini, G ;

Grandi, D ;

Stark, HB ;

Schunack, W .

BRITISH JOURNAL OF PHARMACOLOGY, 2000, 129 (08) :1597-1600

[46]

MZANEVA MA, 2003, ACTA HISTOCHEM, V105, P191

[47] Regulation and function of COX-2 gene expression in isolated gastric parietal cells [J].

Pausawasdi, N ;

Ramamoorthy, S ;

Crofford, LJ ;

Askari, FK ;

Todisco, A .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2002, 282 (06) :G1069-G1078

[48]

Pavlov I. P., 1910, LECT WORK PRINCIPAL

[49]

RENY C, 2007, CELL PHYSIOL BIOCHEM, V19, P33

[50] Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues [J].

Rindi, G ;

Necchi, V ;

Savio, A ;

Torsello, A ;

Zoli, M ;

Locatelli, V ;

Raimondo, F ;

Cocchi, D ;

Solcia, E .

HISTOCHEMISTRY AND CELL BIOLOGY, 2002, 117 (06) :511-519

← 1 2 3 4 5 6 7 →