BRAIN-GUT AND APPETITE REGULATING HORMONES IN THE CONTROL OF GASTRIC SECRETION AND MUCOSAL PROTECTION

被引：0
作者：
Konturek, S. J. [1 ]
Brzozowski, T. [1 ]
Konturek, P. C. [2 ]
Schubert, M. L. [3 ]
Pawlik, W. W. [1 ]
Padol, S. [1 ]
Bayner, J. [1 ]
机构：
[1] Jagiellonian Univ, Coll Med, Dept Clin Physiol, PL-31531 Krakow, Poland
[2] Univ Erlangen Nurnberg, Dept Med 1, Erlangen, Germany
[3] Virginia Commonwealth Univ, Med Coll Virginia, Richmond, VA 23298 USA
来源：
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2008年 / 59卷
关键词：
gastric acid; mucosal damage; gastroprotection; vagal nerves; gastrin; ghrelin; leptin; melatonin;
D O I：
暂无
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The progress in basic and clinical gastrology indicates that gastric mucosal integrity represents a balance between offensive and defensive factors, The main offensive factors appear to be gastric acid and pepsin under health conditions, while the nonsteroidal anti-inflammatory drugs (NSAID) and Helicobacter pylori (H. pylori), infecting this mucosa, are currently considered the most important "aggressive" factors under pathological conditions. To the list of the aggressive factors, also stress, certain cytokines (TNF-alpha, IL-8, IL-11 and IL-18) and oxygen or nitrogen free radicals should be added. The aims of this review is the presentation of the involvement of aggressive and protective factors in the control of gastric acid secretion and appetite regulating hormones in maintaining gastric mucosal integrity and its protection against damaging factors.
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页码：7 / 31
页数：25
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