Hydrogen-Free Alkene Reduction in Continuous Flow

被引：52
作者：
Kleinke, Andrew S. [1 ]
Jamison, Timothy F. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 03期
关键词：
ACTIVATED ACYL GROUPS; AEROBIC REDUCTION; DIIMIDE; GENERATION; HYDROXYLAMINE; MECHANISM; NITRILES; OLEFINS; REACTOR; SAFE;
D O I：
10.1021/ol400051n
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first continuous hydrogenation that requires neither H-2 nor metal catalysis generates diimide by a novel reagent combination. The simple flow reactor employed minimizes residence time by enabling safe operation at elevated temperature.
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页码：710 / 713
页数：4
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