HMDB 3.0-The Human Metabolome Database in 2013

被引：2247

作者：

Wishart, David S. ^{[1
,2
,3
]}

Jewison, Timothy ^{[1
]}

Guo, An Chi ^{[1
]}

Wilson, Michael ^{[1
]}

Knox, Craig ^{[1
]}

Liu, Yifeng ^{[1
]}

Djoumbou, Yannick ^{[2
]}

Mandal, Rupasri ^{[1
]}

Aziat, Farid ^{[2
]}

Dong, Edison ^{[1
]}

Bouatra, Souhaila ^{[2
]}

Sinelnikov, Igor ^{[2
]}

Arndt, David ^{[1
]}

Xia, Jianguo ^{[2
]}

Liu, Philip ^{[1
]}

Yallou, Faizath ^{[1
]}

Bjorndahl, Trent ^{[1
]}

Perez-Pineiro, Rolando ^{[1
]}

Eisner, Roman ^{[1
]}

Allen, Felicity ^{[1
]}

Neveu, Vanessa ^{[4
]}

Greiner, Russ ^{[1
]}

Scalbert, Augustin ^{[4
]}

机构：

[1] Univ Alberta, Dept Comp Sci, Edmonton, AB T6G 2E8, Canada

[2] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E8, Canada

[3] Natl Inst Nanotechnol, Edmonton, AB T6G 2M9, Canada

[4] Int Agcy Res Canc, IARC Biomarkers Grp, F-69372 Lyon 08, France

来源：

NUCLEIC ACIDS RESEARCH | 2013年 / 41卷 / D1期

基金：

加拿大健康研究院;

关键词：

MASS; PREDICTION; PATHWAYS;

D O I：

10.1093/nar/gks1065

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Human Metabolome Database (HMDB) (www.hmdb.ca) is a resource dedicated to providing scientists with the most current and comprehensive coverage of the human metabolome. Since its first release in 2007, the HMDB has been used to facilitate research for nearly 1000 published studies in metabolomics, clinical biochemistry and systems biology. The most recent release of HMDB (version 3.0) has been significantly expanded and enhanced over the 2009 release (version 2.0). In particular, the number of annotated metabolite entries has grown from 6500 to more than 40 000 (a 600% increase). This enormous expansion is a result of the inclusion of both 'detected' metabolites (those with measured concentrations or experimental confirmation of their existence) and 'expected' metabolites (those for which biochemical pathways are known or human intake/exposure is frequent but the compound has yet to be detected in the body). The latest release also has greatly increased the number of metabolites with biofluid or tissue concentration data, the number of compounds with reference spectra and the number of data fields per entry. In addition to this expansion in data quantity, new database visualization tools and new data content have been added or enhanced. These include better spectral viewing tools, more powerful chemical substructure searches, an improved chemical taxonomy and better, more interactive pathway maps. This article describes these enhancements to the HMDB, which was previously featured in the 2009 NAR Database Issue. (Note to referees, HMDB 3.0 will go live on 18 September 2012.).

引用

页码：D801 / D807

页数：7

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