Overview of Hematopoietic Cell Transplantation for the Treatment of Hematologic Malignancies

被引：12

作者：

Singh, Nathan ^{[1
]}

Loren, Alison W. ^{[1
]}

机构：

[1] Univ Penn, Perelman Sch Med, Perelman Ctr Adv Med, 6th Floor,Room 627,3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA

来源：

CLINICS IN CHEST MEDICINE | 2017年 / 38卷 / 04期

关键词：

Allogeneic hematopoietic cell transplantation; Hematologic malignancies; Graft-versus-host disease; Complications; VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; CORD-BLOOD TRANSPLANTATION; ACUTE MYELOID-LEUKEMIA; DONOR LEUKOCYTE INFUSIONS; LONG-TERM SURVIVORS; REVERSIBLE ENCEPHALOPATHY SYNDROME; CHRONIC MYELOGENOUS LEUKEMIA; RECEPTOR T-CELLS; STEM-CELL;

D O I：

10.1016/j.ccm.2017.07.001

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Allogeneic hematopoietic cell transplantation offers the best chance for cure in many hematologic malignancies. Key decisions include patient selection, donor and graft source, conditioning regimen, and graft-versus-host disease (GVHD) prophylaxis. Transplant is risky; only one-third survive long term. Complications include relapse, GVHD, infection, and end-organ dysfunction. Expanding indications for transplantation, advancing upper age limits, and improvements in patient care have resulted in increasing numbers of transplant survivors. These patients may suffer substantial long-term health consequences and require intensive follow-up. Future directions include graft engineering and cellular therapy, optimizing donor selection, sensitive disease assessments and/or maintenance therapies, and improvements in care.

引用

页码：575 / +

页数：20

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