Genetic Variants Associated with Lipid Profiles in Chinese Patients with Type 2 Diabetes

被引：13
作者：
Kong, Xiaomu [1 ]
Zhao, Qi [2 ]
Xing, Xiaoyan [1 ]
Zhang, Bo [1 ]
Zhang, Xuelian [1 ]
Hong, Jing [1 ]
Yang, Wenying [1 ]
机构：
[1] China Japan Friendship Hosp, Dept Endocrinol, Beijing, Peoples R China
[2] Tulane Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA
来源：
PLOS ONE | 2015年 / 10卷 / 08期
基金：
美国国家卫生研究院; 中国博士后科学基金;
关键词：
GENOME-WIDE ASSOCIATION; CORONARY-ARTERY-DISEASE; CARDIOVASCULAR-DISEASE; LOCI; RISK; POPULATION; TRANSCRIPTION; PREVALENCE; PROTEIN; TRAITS;
D O I：
10.1371/journal.pone.0135145
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Dyslipidemia is a strong risk factor for cardiovascular disease among patients with type 2 diabetes (T2D). The aim of this study was to identify lipid-related genetic variants in T2D patients of Han Chinese ancestry. Among 4,908 Chinese T2D patients who were not taking lipid-lowering medications, single nucleotide polymorphisms (SNPs) in seven genes previously found to be associated with lipid traits in genome-wide association studies conducted in populations of European ancestry (ABCA1, GCKR, BAZ1B, TOMM40, DOCK7, HNF1A, and HNF4A) were genotyped. After adjusting for multiple covariates, SNPs in ABCA1, GCKR, BAZ1B, TOMM40, and HNF1A were identified as significantly associated with triglyceride levels in T2D patients (P < 0.05). The associations between the SNPs in ABCA1 (rs3890182), GCKR (rs780094), and BAZ1B (rs2240466) remained significant even after correction for multiple testing (P = 8.85x10(-3), 7.88x10(-7), and 2.03x10(-6), respectively). BAZ1B (rs2240466) also was associated with the total cholesterol level (P = 4.75x10(-2)). In addition, SNP rs157580 in TOMM40 was associated with the low-density lipoprotein cholesterol level (P = 6.94x10(-3)). Our findings confirm that lipid-related genetic loci are associated with lipid profiles in Chinese patients with type 2 diabetes.
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页数：13
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