DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia

被引：17

作者：

Borssen, Magnus ^{[1
]}

Nordlund, Jessica ^{[2
,3
]}

Haider, Zahra ^{[1
]}

Landfors, Mattias ^{[1
]}

Larsson, Par ^{[1
]}

Kanerva, Jukka ^{[4
]}

Schmiegelow, Kjeld ^{[5
,6
]}

Flaegstad, Trond ^{[7
,8
]}

Jonsson, Olafur Gisli ^{[9
]}

Frost, Britt-Marie ^{[10
]}

Palle, Josefine ^{[10
]}

Forestier, Erik ^{[1
]}

Heyman, Mats ^{[11
]}

Hultdin, Magnus ^{[1
]}

Lonnerholm, Gudmar ^{[10
]}

Degerman, Sofie ^{[1
]}

机构：

[1] Umea Univ, Dept Med Biosci, Blg 6M,2nd Floor, SE-90185 Umea, Sweden

[2] Uppsala Univ, Dept Med Sci, Uppsala, Sweden

[3] Uppsala Univ, Sci Life Lab, Uppsala, Sweden

[4] Univ Helsinki, Cent Hosp, Childrens Hosp, Helsinki, Finland

[5] Univ Copenhagen, Rigshosp, Dept Paediat & Adolescent Med, Copenhagen, Denmark

[6] Univ Copenhagen, Inst Clin Med, Copenhagen, Denmark

[7] Univ Tromso, Dept Pediat, Tromso, Norway

[8] Univ Hosp North Norway, Tromso, Norway

[9] Landspitali Univ Hosp, Childrens Hosp, Pediat Hematol Oncol, Reykjavik, Iceland

[10] Uppsala Univ, Dept Womens & Childrens Hlth, Pediat, Uppsala, Sweden

[11] Karolinska Univ Hosp, Karolinska Inst, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden

来源：

CLINICAL EPIGENETICS | 2018年 / 10卷

基金：

瑞典研究理事会;

关键词：

DNA methylation; BCP-ALL; Prognosis; CIMP; Relapse; Risk stratification; MINIMAL RESIDUAL DISEASE; LESSONS;

D O I：

10.1186/s13148-018-0466-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients. Methods: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1-18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data. Results: Among the 137 patients that later relapsed, patients with a CIMP-profile (n = 42) at initial diagnosis had an inferior overall survival (pOS(5years) 33%) compared to CIMP+ patients (n = 95, pOS(5years) 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors. Conclusion: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL.

引用

页数：7

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