Oxidative stress mediated cytotoxicity of TiO2 nano anatase in liver and kidney of Wistar rat

被引：41
作者：
Meena, R. [1 ]
Paulraj, R. [1 ]
机构：
[1] Jawaharlal Nehru Univ, Sch Environm Sci, New Delhi 110067, India
来源：
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY | 2012年 / 94卷 / 01期
关键词：
oxidative stress; micronuclei induction; antioxidative enzymes; apoptosis; TITANIUM-DIOXIDE NANOPARTICLES; ULTRAFINE PARTICLES; IN-VITRO; TOXICITY; TRANSLOCATION; GENOTOXICITY; FINE;
D O I：
10.1080/02772248.2011.638441
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
This study examined the adverse effects of TiO2 nanoparticle (nano-TiO2) on the kidney and liver of Wistar rats. Changes of serum biochemical parameters and pathological lesions indicated that liver and kidney were significantly affected in animals treated with 50 mg kg(-1) of nano-TiO2. The inverse relationship between the level of reactive oxygen species and the activities of superoxide dismutase, catalase, and glutathione peroxidase indicates that nano-TiO2 induces oxidative stress. A significant increase in the apoptosis of liver and kidney in a dose-dependent manner was also observed. The ultrastructural observations confirmed the internalization of nano-TiO2 and their direct involvement in the mitochondria- mediated cytotoxicity. Data indicated that nano-TiO2 induce oxidative stress which produces genotoxicity such as oxidative DNA damage, micronuclei (MN) induction, and cell apoptosis in liver and kidney.
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页码：146 / 163
页数：18
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